Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6NFR6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6NFR6-F1 | Predicted | AlphaFoldDB |
3 variants for A6NFR6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1319931 VAR_044323 |
55 | R>C | No |
UniProt dbSNP |
|
|
VAR_044324 rs13168357 |
56 | L>P | No |
UniProt dbSNP |
|
| VAR_062961 | 70 | E>del | No | UniProt |
No associated diseases with A6NFR6
10 regional properties for A6NFR6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA topoisomerase, type IA, domain 2 | 104 - 192 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 242 - 508 | IPR003602 |
| domain | TOPRIM domain | 3 - 113 | IPR006171 |
| domain | DNA topoisomerase, type IA, central | 77 - 90 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 128 - 556 | IPR013497-2 |
| domain | DNA topoisomerase, type IA, zn finger | 574 - 611 | IPR013498-1 |
| domain | DNA topoisomerase, type IA, zn finger | 614 - 653 | IPR013498-2 |
| domain | DNA topoisomerase, type IA, zn finger | 655 - 688 | IPR013498-3 |
| active_site | DNA topoisomerase, type IA, active site | 279 - 302 | IPR023406 |
| domain | DNA topoisomerase 1, TOPRIM domain | 4 - 125 | IPR034149 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRAQLPEDS | SAVDMDILFP | LDSVIGTELC | PSPIPQIIHF | VLFVVFSLVI | LIILRLYIPR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPSSVPPREE | DSENDQAEVG | EWLRIGNKYI | TLKDYRILLK | ELENLEIYTF | LSKKCLKKLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REGSSHHLPR | QVRPGPVYKP | APARNHRPRG | GRGKASPTSF | HVSPRAPLAP | LASMPSSVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSVESLGSPS | SLSSSKPREP | LCPLKHPSHQ | PPASTLSPNP | TSSTESLGYL | SSLSSSQPPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PLRPLKHPSH | KPRGRSLPRR | RNPGWVSWSD | SMQADSETDT | IICPMCKAPE | RSCPHTWWVP |
| 310 | 320 | 330 | 340 | 350 | |
| SSPRVIRGVG | RCSDPNLGLS | WRQEAARAWC | HCTSSQFPFK | HPNLPTHLPK | ASF |