A6NC05
PR
Gene name |
C5orf63 |
Protein name |
Glutaredoxin-like protein C5orf63 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:401207 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6NC05
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6NC05-F1 | Predicted | AlphaFoldDB |
103 variants for A6NC05
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1037167919 CA360820348 |
3 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
CA127423996 rs1037167919 CA360820347 |
3 | W>C | No |
ClinGen TOPMed gnomAD |
|
|
CA127423994 rs928909666 |
6 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA127423992 rs188886844 |
7 | N>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA127423991 rs949101591 |
8 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1212534742 CA360820308 |
9 | M>T | No |
ClinGen gnomAD |
|
|
rs916229349 CA127423989 |
9 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs904773366 CA127423987 |
11 | L>I | No |
ClinGen gnomAD |
|
|
rs529537151 CA3391132 |
11 | L>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs563543864 CA3391131 |
13 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA360820277 rs1342155287 |
14 | S>F | No |
ClinGen gnomAD |
|
|
CA360820279 rs990994638 |
14 | S>P | No |
ClinGen TOPMed |
|
|
CA127423984 rs990994638 |
14 | S>T | No |
ClinGen TOPMed |
|
|
CA127423982 rs957754505 |
17 | G>V | No |
ClinGen TOPMed |
|
|
rs1561490318 CA360820255 |
18 | L>F | No |
ClinGen Ensembl |
|
|
CA360820252 rs1271822091 |
18 | L>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1271822091 CA360820250 |
18 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
CA127423980 rs912034273 |
24 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
rs752538265 CA127423977 |
26 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1294542197 CA360820185 |
28 | T>A | No |
ClinGen gnomAD |
|
|
rs1443285258 CA360820179 |
29 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1334740160 CA360820176 |
29 | T>N | No |
ClinGen gnomAD |
|
|
CA360820165 rs1411438570 |
31 | P>L | No |
ClinGen gnomAD |
|
|
rs1329314230 CA360820168 |
31 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 32 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360820133 rs1295619638 |
36 | F>S | No |
ClinGen TOPMed |
|
|
rs1407581039 CA360820101 |
39 | D>G | No |
ClinGen gnomAD |
|
|
rs1159344003 CA360820095 |
40 | P>S | No |
ClinGen gnomAD |
|
|
rs1159344003 CA360820097 |
40 | P>T | No |
ClinGen gnomAD |
|
|
rs745777421 CA127422752 |
42 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
rs745777421 CA127422751 |
42 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA360820080 rs745777421 |
42 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA360820063 rs1323014511 |
45 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA360820042 rs1193324708 |
48 | K>E | No |
ClinGen gnomAD |
|
|
CA360820020 rs1248953114 |
51 | L>V | No |
ClinGen gnomAD |
|
|
CA360820001 rs1190556674 |
54 | Y>H | No |
ClinGen TOPMed |
|
|
rs769377129 CA3391116 |
55 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA127422743 rs777748493 |
56 | N>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1046482109 CA127421911 |
59 | P>A | No |
ClinGen Ensembl |
|
|
rs1012737090 CA360819295 |
59 | P>H | No |
ClinGen TOPMed gnomAD |
|
|
CA127421909 rs1012737090 |
59 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA360819289 rs1361769345 |
60 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1157896711 CA360819284 |
61 | K>E | No |
ClinGen gnomAD |
|
|
rs1419239018 CA360819281 |
61 | K>T | No |
ClinGen gnomAD |
|
|
rs1049100522 CA127421908 |
62 | D>V | No |
ClinGen TOPMed |
|
|
CA3391088 rs780381548 |
63 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs1366013349 CA360819263 |
64 | K>Q | No |
ClinGen TOPMed |
|
|
CA127421904 rs994790935 |
65 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
COSM4159385 rs753391035 CA127421902 |
66 | P>A | thyroid [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs897944746 CA360819237 |
68 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
CA127421900 rs897944746 |
68 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1210583797 CA360819218 |
71 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs534484470 CA3391087 |
72 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3391086 rs750575443 |
72 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA360819205 rs1385104006 |
73 | S>F | No |
ClinGen TOPMed |
|
|
CA360819208 rs1238610823 |
73 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1299146562 CA360819193 |
75 | S>F | No |
ClinGen TOPMed |
|
|
CA127421893 rs575131354 |
76 | S>* | No |
ClinGen 1000Genomes TOPMed |
|
|
CA360819182 rs1232521760 |
77 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA360819171 rs1297271034 |
79 | H>R | No |
ClinGen gnomAD |
|
|
CA360819164 rs1324774663 |
80 | P>L | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 80 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1042580301 CA127421889 |
81 | H>D | No |
ClinGen gnomAD |
|
|
rs1042580301 CA360819161 |
81 | H>N | No |
ClinGen gnomAD |
|
|
rs1490051471 CA360819149 |
82 | M>I | No |
ClinGen TOPMed |
|
|
rs369567694 CA3391084 |
82 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1207518613 CA360819141 |
83 | A>V | No |
ClinGen TOPMed |
|
|
CA127421885 rs987279680 |
85 | Q>P | No |
ClinGen Ensembl |
|
|
CA3391082 rs537960991 |
86 | S>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1426598712 CA360819109 |
88 | K>N | No |
ClinGen gnomAD |
|
|
rs539226324 CA127421881 |
91 | N>S | No |
ClinGen Ensembl |
|
|
rs1204581719 CA360819085 |
92 | L>V | No |
ClinGen gnomAD |
|
|
CA360819070 rs1365147966 |
94 | L>S | No |
ClinGen TOPMed |
|
|
rs1561486818 CA360819057 |
96 | Q>E | No |
ClinGen Ensembl |
|
|
CA360819049 rs1456492968 |
97 | V>I | No |
ClinGen TOPMed |
|
|
CA360819034 rs1299949463 |
99 | S>T | No |
ClinGen TOPMed |
|
|
rs921650280 CA127421879 |
102 | Y>C | No |
ClinGen Ensembl |
|
|
CA360818987 rs1288388745 |
105 | G>R | No |
ClinGen gnomAD |
|
|
rs1347592296 CA360818961 |
109 | P>A | No |
ClinGen gnomAD |
|
|
CA360818943 rs1275749686 |
111 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA360818945 rs1275749686 |
111 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
CA360818916 rs1325153043 |
115 | D>E | No |
ClinGen gnomAD |
|
|
CA3391078 rs760298235 |
115 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA360818909 rs1294256181 |
116 | C>F | No |
ClinGen gnomAD |
|
|
rs1330517961 CA360818913 |
116 | C>R | No |
ClinGen TOPMed |
|
|
CA127421876 rs750387389 |
117 | G>E | No |
ClinGen Ensembl |
|
| TCGA novel | 119 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360818885 rs1445342704 |
120 | Y>C | No |
ClinGen gnomAD |
|
|
CA127421872 rs963014129 |
120 | Y>H | No |
ClinGen TOPMed |
|
|
rs1310687506 CA360818864 |
123 | R>T | No |
ClinGen gnomAD |
|
|
rs541525107 CA127421871 |
124 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA360818846 rs1174070928 |
125 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA127421869 rs539050968 |
126 | K>R | No |
ClinGen 1000Genomes |
|
|
CA360818822 rs1194336309 |
129 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA360818821 rs1194336309 |
129 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA127421865 rs752867000 |
130 | M>K | No |
ClinGen TOPMed gnomAD |
|
|
CA360818813 rs752867000 |
130 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA127421867 rs1004768464 |
130 | M>V | No |
ClinGen Ensembl |
|
|
CA127421863 rs1045727282 |
131 | T>N | No |
ClinGen TOPMed |
|
|
rs1462961203 CA360818791 |
133 | C>Y | No |
ClinGen TOPMed |
|
|
rs948367057 CA127421861 |
134 | F>S | No |
ClinGen TOPMed |
|
|
CA3391075 rs771567552 |
136 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1265687946 CA360818755 |
138 | Q>R | No |
ClinGen gnomAD |
No associated diseases with A6NC05
No regional properties for A6NC05
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A6NC05 | |||
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLWFQGNSMQ | LARSSFGLFL | RNCSASKTTL | PVLTLFTKDP | CPLCDEAKEV | LKPYENRQPY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDQKLPGTRR | RRSPSSPSHP | HMASQSGKRY | NLTLNQVLSF | DYDMGLDAPK | TISSDCGAFY |
| 130 | |||||
| CLRMFKSPDM | TCCFYPKQ |