A6LSF6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
KEGG Pathway
cbe:Cbei_1104
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

388-465 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6LSF6

Entry ID Method Resolution Chain Position Source
AF-A6LSF6-F1 Predicted AlphaFoldDB

No variants for A6LSF6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6LSF6

No associated diseases with A6LSF6

8 regional properties for A6LSF6

Type Name Position InterPro Accession
domain Protein kinase domain 151 - 409 IPR000719
domain AGC-kinase, C-terminal 410 - 481 IPR000961
domain Pleckstrin homology domain 5 - 110 IPR001849
active_site Serine/threonine-protein kinase, active site 271 - 283 IPR008271
binding_site Protein kinase, ATP binding site 157 - 190 IPR017441
domain Protein kinase, C-terminal 430 - 475 IPR017892
domain Protein kinase B alpha, catalytic domain 125 - 479 IPR034676
domain Protein Kinase B, pleckstrin homology domain 4 - 111 IPR039026

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFMKTNDLR EAYLKFFESK DHLRMDSFSL VPKNDKSLLL INAGMAPLKP YFTGLQEPPK
70 80 90 100 110 120
RRITTCQKCI RTGDIENVGI TSRHGTFFEM LGNFSFADYF KKEIIPWAWE FITEVLELPK
130 140 150 160 170 180
DRLYVTIYLD DDEAYEYWTT LTDVDKTHIF RLGKEDNFWE HGAGPCGPCT EIHFNRSEEI
190 200 210 220 230 240
PTNADEFVKL ADEDKIIEFW NLVFTQFDGD GKGNYEKLAN TNIDTGMGLE RLATIMQEKN
250 260 270 280 290 300
SIFEIDTLEN ILSEVAKLAN VKYGENQKTD ISLRLITDHI RSITFMISDD VMPSNEGRGY
310 320 330 340 350 360
VLRRLLRRAA RHGKTLGIKE AFLCNLCDTV IRDSSEAYPE LNSKKEYIKK VIKIEEDKFR
370 380 390 400 410 420
ETLDSGMEIL NGFISELKAK NEKVLSGVDG FKLYDTFGFP MELTKEILED EGLSLDEDAF
430 440 450 460 470 480
HEEMKVQRER ARSARKVSNY MGTDVKTLDI IPAEVETVFD GYDNDTLNAE VKVLIEGEDF
490 500 510 520 530 540
TDAITEGNKA IIVTDVTPLY AEMGGQIGDT GVIFNDGFKA NVLDTKKNIG GKIVHFVEVV
550 560 570 580 590 600
SGELKVGDTV TIEVDKVRRE NIKKNHTATH LLDKALTEVL GSHVHQAGSY VSNDRLRFDF
610 620 630 640 650 660
SHFEAMTEEE INKVEDLVNE AITSVTPVVT EVMDLQEAKN SGAIGIFDDK YADKVRVVSA
670 680 690 700 710 720
GEYSKELCGG THIDNTGKIG LFKIISESGI AAGTRRIEAV IGKEAYKIVN EKKDLLKEIS
730 740 750 760 770 780
TKLKCSEKEL LAKLDQQVKE LKEKDKEITA LKSKFASMGI DDIVSSSRNV KDINVISYEL
790 800 810 820 830 840
KDVDSDTLRD VCEKVRDKAP NSIVLLMSAN AGKVIICAMA TKDAVAKGAH CGKLIKEISS
850 860 870
MLGGGGGGRP DMAQAGGKMP EKIQEAIEES YKIVETLAK