A6LP90
Gene name |
thyX |
Protein name |
Flavin-dependent thymidylate synthase |
Names |
FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase |
Species |
Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429) |
KEGG Pathway |
tme:Tmel_1909 |
EC number |
2.1.1.148: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6LP90
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6LP90-F1 | Predicted | AlphaFoldDB |
No variants for A6LP90
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6LP90 | |||||
No associated diseases with A6LP90
No regional properties for A6LP90
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A6LP90 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.148 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| thymidylate synthase (FAD) activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dTMP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
| dTTP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEFKVLDKGF | LRLVDILGDD | YSAVKAARVS | YGKGIKTPEK | DKNLIFYLME | HKHETPFEHI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VFTFHVKTPI | FVARQWFRHR | IGSFNEASLR | YTELKDEFYL | PDHIRKNIVE | DKQKAVRVEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKLKEQALEL | IYNSIEDSYK | VYRKLLELGV | AREMARIVLP | MSSYTQFYWT | VNARSLMNFL |
| 190 | 200 | 210 | 220 | ||
| NLRADSHAQW | EIQQYAIKIA | KIFKEKCPWT | FESFLKFNYR | GDILREVEL |