A6LEU3

PR
Gene name
murG
Protein name
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Names
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Species
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
KEGG Pathway
pdi:BDI_2487
EC number
2.4.1.227: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

255-324 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6LEU3

Entry ID Method Resolution Chain Position Source
AF-A6LEU3-F1 Predicted AlphaFoldDB

No variants for A6LEU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6LEU3

No associated diseases with A6LEU3

2 regional properties for A6LEU3

Type Name Position InterPro Accession
domain Glycosyltransferase family 28, N-terminal domain 6 - 144 IPR004276
domain Glycosyl transferase, family 28, C-terminal 193 - 347 IPR007235

Functions

Description
EC Number 2.4.1.227 Hexosyltransferases
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP.
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP.

7 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKYRIIISG GGTGGHIFPA ISIANTFKKR FPDAEILFVG AEDRMEMDKV PAAGYKIVGL
70 80 90 100 110 120
PVSGFDRAHL MNNVKVMVRL AKSLRLARKT IREFKPDIAV GVGGYASGPT LWMAASQGVP
130 140 150 160 170 180
ALIQEQNSYA GVTNKLLAKK ASKICVAYEG MEKFFPADKI VITGNPVRQD LEEALSKKEE
190 200 210 220 230 240
ALAFFGLSPE KKTILVVGGS LGARTINRSI QGDLDKFFAS DVQVIWQTGR YYYSDASKHL
250 260 270 280 290 300
KAYRGMPVWC SDFITRMDYA YSAADLVISR AGASSISELC LLGKPVVLVP SPNVAEDHQT
310 320 330 340 350 360
KNALALVHKD AAVMIADKDA EKDLVPTALK IVHDDERLCT LSRNIETLAQ RHSADRIVDE
IVKIIDKK