A6LEL4
Gene name |
metK |
Protein name |
S-adenosylmethionine synthase |
Names |
AdoMet synthase, MAT, Methionine adenosyltransferase |
Species |
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) |
KEGG Pathway |
pdi:BDI_2403 |
EC number |
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6LEL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6LEL4-F1 | Predicted | AlphaFoldDB |
No variants for A6LEL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6LEL4 | |||||
No associated diseases with A6LEL4
5 regional properties for A6LEL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosylmethionine synthetase, N-terminal | 2 - 99 | IPR022628 |
| domain | S-adenosylmethionine synthetase, central domain | 113 - 252 | IPR022629 |
| domain | S-adenosylmethionine synthetase, C-terminal | 254 - 387 | IPR022630 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 115 - 125 | IPR022631-1 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 280 - 288 | IPR022631-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.6 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYLFTSESV | SEGHPDKVAD | QISDALLDEF | LAYDKNSKVA | CETLVTTGQV | VLAGEVKSSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YVDVQEVARG | VIEKIGYTKS | EYQFEAKSCG | VFSSIHEQSG | DINRGVERAD | PYEQGAGDQG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MMFGYATNET | ENYMPLALDL | SHSLLWELAK | IRKEEPDLMP | YLRPDAKSQV | TIEYDDNGKP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRIDTIVVST | QHDEFIGPKG | ISQKEADEAM | QKRIALDVKK | ILIPRVKAQY | PAHVQALFND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NIIYHVNPTG | KFVIGGPHGD | TGLTGRKIIV | DTYGGKGAHG | GGAFSGKDPS | KVDRSAAYAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RHIAKNMVAA | GVADEMLVQV | SYAIGVAKPM | NIFVNTFGRA | KVNMTDGEIA | AKIWDIFDMR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKAIEERLKL | RNPIYFETAS | YGHMGRKPQT | VTKTFSSRYL | QKPVTCDVEL | FTWEKLDYAD |
| KIKDVFGL |