A6H690

PR
Gene name
Iqca1l (Iqca1p1)
Protein name
IQ and AAA domain-containing protein 1-like
Names
Protein IQCA1P1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:231045
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6H690

Entry ID Method Resolution Chain Position Source
AF-A6H690-F1 Predicted AlphaFoldDB

34 variants for A6H690

Variant ID(s) Position Change Description Diseaes Association Provenance
rs260391599 25 P>S No EVA
rs237747175 130 S>G No EVA
rs265230610 144 N>S No EVA
rs243850919 211 I>V No EVA
rs29561407 227 E>K No EVA
rs32005610 249 L>M No EVA
rs247110357 379 V>A No EVA
rs3388749660 384 E>* No EVA
rs3388749635 385 V>L No EVA
rs32006549 388 R>K No EVA
rs3388748091 404 E>K No EVA
rs261364547 408 V>M No EVA
rs3413113849 413 Y>* No EVA
rs242060510 434 Q>E No EVA
rs3388745231 449 Q>* No EVA
rs3388733341 460 R>M No EVA
rs3388749994 495 L>Q No EVA
rs3412959395 522 Y>F No EVA
rs3394725549 583 Q>* No EVA
rs3388733389 584 A>V No EVA
rs3388736875 613 L>P No EVA
rs33056918 649 T>K No EVA
rs3388742372 654 R>G No EVA
rs3388740424 664 K>* No EVA
rs3388733381 664 K>N No EVA
rs3388740424 664 K>Q No EVA
rs240192454 717 S>N No EVA
rs223271040 720 R>M No EVA
rs3388747759 739 G>D No EVA
rs3388722120 754 T>R No EVA
rs32010074 773 G>V No EVA
rs48902370 806 T>S No EVA
rs32010083 815 A>V No EVA
rs29776345 818 T>A No EVA

No associated diseases with A6H690

2 regional properties for A6H690

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 206 - 235 IPR000048
domain ATPase, AAA-type, core 568 - 696 IPR003959

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VQN8 CG3326 Fidgetin-like protein 1 Drosophila melanogaster (Fruit fly) PR
Q6PIW4 FIGNL1 Fidgetin-like protein 1 Homo sapiens (Human) PR
Q9UBP0 SPAST Spastin Homo sapiens (Human) PR
Q86XH1 IQCA1 Dynein regulatory complex protein 11 Homo sapiens (Human) PR
A6NCM1 IQCA1L IQ and AAA domain-containing protein 1-like Homo sapiens (Human) PR
Q9CUL5 Iqca1 Dynein regulatory complex protein 11 Mus musculus (Mouse) PR
Q6AXQ7 Iqca1l IQ and AAA domain-containing protein 1-like Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSEGTYQRLW EASHVTLEEV LEKEPSVLEP VPSRERQSFQ YRISVLYLYY LGLLRRFNLA
70 80 90 100 110 120
YDQMVQPQKR RLLRRLLDGV AGRVLELKDE LVRVDLCETH CLDRVLQDLK LTPADLEVPI
130 140 150 160 170 180
PKYFQLEQSS AVKARQQMLA DILNRLEPLV SQENLRGLSR TAALILVQSA ERARQGRLRA
190 200 210 220 230 240
TFMREIRKEE ERDRRIWENG QQKFSRDQGA IVIQKVWKGY LQRKRIEQDR RVEMEFIGML
250 260 270 280 290 300
PSPNQTARLN TLNQAFLGEE SRRMRQVEKE EEFQEAIGKT YESLTETEGP DMKERMKDQI
310 320 330 340 350 360
RQWFIECHAL TGRFPDYPDE ASGGSYLIFA DKTPEQVRLD LEAQAQESRK KDQEKKEKNK
370 380 390 400 410 420
EKEKEKKEKK KKKVKEEKVK KEPEVMFRVL PSKSIPVINA GHEEYTSVWK SRYDNKHPSQ
430 440 450 460 470 480
NFDSETLREE KRKQVEMEIR VQVDELMRQE LKNLRLAVDR EETRPLKSPK KKGGKKSGKK
490 500 510 520 530 540
KKEKDLTPDR SVDSLFEELV IIGLIKKSAL VTLSDYIGDC LYLGSTLTLA NKMPMPSLFD
550 560 570 580 590 600
IRQNMALYGV LRLGSHDIHT MAPLVRSILL VGPSGMGKKM LVQAVCTETG ANLFDLSPDN
610 620 630 640 650 660
LMGKYPGKNG AQLLVHIVFK VARLLQPSVI WIGNTEKTFY KKVPKEERTM DPKRIKKDLM
670 680 690 700 710 720
RATKQLSPGD RVMLIGTTER PQLAEMKGLC RFYERILFIP RPDYASRYVL WKRMIESQGR
730 740 750 760 770 780
GVQLTSSLDV SALARVSDGY TPSHILQSIQ SVLTERRLLQ LIKKPLVASE FVGHLARLDP
790 800 810 820
VYREEEESLK EWFFKTPLGK KNMKFTKDQL EAEEARLTKE KKKKK