A5WG58

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Psychrobacter sp (strain PRwf-1)
KEGG Pathway
prw:PsycPRwf_1709
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

530-612 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5WG58

Entry ID Method Resolution Chain Position Source
AF-A5WG58-F1 Predicted AlphaFoldDB

No variants for A5WG58

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5WG58

No associated diseases with A5WG58

8 regional properties for A5WG58

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 11 - 22 IPR001412
domain tRNA-binding domain 595 - 697 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 569 - 696 IPR004495
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 427 - 512 IPR013155
domain Methionyl/Leucyl tRNA synthetase 4 - 407 IPR015413
domain Methioninyl-tRNA synthetase core domain 4 - 377 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 395 - 406 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 387 - 517 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRQILVTSAL PYANGPIHLG HLVEYIQTDI WVRAMKAQSH QVTYVCADDA HGTAIMLKAE
70 80 90 100 110 120
ANGVTPEQQI ATVKASHEAD FSKFLIGFDN YHSTHSEENR ELSELIYRRL NGEGHISTKD
130 140 150 160 170 180
VEQLFDPEKG LFLADRFVKG ECPECGAQDQ YGDNCEVCGT TYNATELKNP YSTLSGATPV
190 200 210 220 230 240
LRTSKHYFFN LPEFESFLKQ WTKDEGRLQP SVSNKLQEWF EAGLASWDIS RDAPYFGFKI
250 260 270 280 290 300
PDTPEGEPDK YFYVWLDAPV GYMASFKNLC KQRQGSTDPQ QPELSFDDYW LQENQHKTEL
310 320 330 340 350 360
YHFIGKDIVY FHALFWPAML AGSEYRTPTG VFAHGFLMVN GDKMSKSRGT FIQAETFAKH
370 380 390 400 410 420
LNPEYLRYYF ASKLSEKVED INLDFADFMQ KVNSDMVGKV VNIASRSAGF IAKKYDGMLS
430 440 450 460 470 480
DSCAEPELLN EIVRAGEEIA TAYENREFSR AMRLIMQCAD KANEYIDSKK PWAMAKEEGR
490 500 510 520 530 540
EQEVQDVCTV AINIFRQLMV YLAPVLPELT DNAKAFLNID DLSFASRHEL LLGHKINKFK
550 560 570 580 590 600
PLMQRIEQAQ IDAMVADSKQ DLLATPTAQA DNVAKAAQAS ETNDQQDSDY IEFDDFMKVE
610 620 630 640 650 660
MTVAQVLECN HVEGADKLLQ FTLDIGKEQP INVFSGIRKF YEPEQLANKK VICVTNLAPR
670 680 690
KMKFGVSEGM ILSSGDPKTG LVVITLPDEC KVGDKLA