A5VLL3

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Limosilactobacillus reuteri (strain DSM 20016) (Lactobacillus reuteri)
KEGG Pathway
lre:Lreu_1491
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-230 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5VLL3

Entry ID Method Resolution Chain Position Source
AF-A5VLL3-F1 Predicted AlphaFoldDB

No variants for A5VLL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5VLL3

No associated diseases with A5VLL3

7 regional properties for A5VLL3

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 333 - 386 IPR000722-1
domain RNA polymerase, alpha subunit 383 - 474 IPR000722-2
domain RNA polymerase, N-terminal 224 - 503 IPR006592
domain RNA polymerase Rpb1, domain 3 478 - 663 IPR007066
domain RNA polymerase Rpb1, domain 1 5 - 331 IPR007080
domain RNA polymerase Rpb1, domain 5 770 - 1131 IPR007081
domain RNA polymerase Rpb1, domain 4 692 - 758 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDVNKFESM QIGLASPDKI RSWSYGEVKK PETINYRTLK PEKQGLFDER IFGPTKDYEC
70 80 90 100 110 120
ACGKYKRIRY KGRVCDRCGV EVTSAKVRRE RMGHIELAAP VSHIWYFKGI PSRMGLVLDM
130 140 150 160 170 180
SPRSLEEVIY FASYVVLDPG DTPLEKKQLL TEAEYRDKKA EYGDRFKAEM GAAAIQKLLA
190 200 210 220 230 240
DVDLEKEAAE LKEELKEATG QKRTRAIRRL DILEAFIKSG NKPEWMVMDV IPVMPPDLRP
250 260 270 280 290 300
MVQLEGGRFA TSDLNDLYRR VINRNNRLKR LLKLQAPGII VQNEKRMLQE AVDALIDNGR
310 320 330 340 350 360
RGRPVAGPGN RPLKSLSHLL KGKQGRFRQN LLGKRVDYSG RSVIDVGPSL KLNQMGLPVP
370 380 390 400 410 420
MALELFKPFI MHELVKRGLS ANVKSAKRKI DRSDDDVFDV LEDVIKEHPV LLNRAPTLHR
430 440 450 460 470 480
LGIQAFEPIL VSGKSMRLHP LVCSAYNADF DGDQMAIHVP LSDEAQAEAR LLMLAAHHIL
490 500 510 520 530 540
SPRDGEPIVS PSQDMVIGNY YMTTEDKGRE GEGMIFKDTD EAELAYRNDY VSLQTRVGVQ
550 560 570 580 590 600
VSAFPEKPFT DDQRGKIMVT TVGKLLFNRI MPKDFAYINE PTDANIQNGV DDRFFLEPGQ
610 620 630 640 650 660
DIHEYLENAP LVPPFKKGFL SDLIAEVYKR YKVTKTSQFL DRIKDLGYYE STISGLTTAM
670 680 690 700 710 720
SDIHDLPEKP EILDKAQKQV TLITKQFRRG LITDDERYER VIGAWNDAKD EVQNKLIEHM
730 740 750 760 770 780
DIHNPINMMS DSGARGNISN FTQLAGMRGL MASPNGKIME LPVKSNFYEG LSVLEMFISS
790 800 810 820 830 840
HGARKGMTDT ALKTANSGYL TRRLVDVAQD VVVREKDCGT DRGLEVTAIT NGNEMIEPLY
850 860 870 880 890 900
DRIMGRYTMK SVFDPKTGEK IVGKNVLIDE EMAQKIVDAG VKKVTIRSAF TCNTEHGVCE
910 920 930 940 950 960
RCYGRNAATG DRVEAGEAVG TVAAQSIGEP GTQLTLRNFH TGGVAGNDDI TQGLPRIQEI
970 980 990 1000 1010 1020
VEARNPKGRA TITEVTGEVV SIEENPAERT KDITIKGETD TRTYTLPITA RMKVAEGDFI
1030 1040 1050 1060 1070 1080
HRGAPLNEGS IDPKELIQVR DVLSTETYLL SQVQGVYRMQ GIDLLDKHVE IMIRQMMRKV
1090 1100 1110 1120 1130 1140
RVMDPGDTDL LPGQLMDISQ FRDANKDTLV AGNIPATARP VILGITKAAL ETNSFLSAAS
1150 1160 1170 1180 1190 1200
FQETTRVLTD AAIRGKNDPL VGLKENVIIG KIIPAGTGMS AYRNIKPKEV SVAAYSIKDI
1210
EAKLKEEDKQ N