A5V3J3
Gene name |
mutL |
Protein name |
DNA mismatch repair protein MutL |
Names |
|
Species |
Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1) (Sphingomonas wittichii) |
KEGG Pathway |
swi:Swit_0491 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5V3J3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5V3J3-F1 | Predicted | AlphaFoldDB |
No variants for A5V3J3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5V3J3 | |||||
No associated diseases with A5V3J3
1 regional properties for A5V3J3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair MutH/Type II restriction enzyme Sau3AI | 19 - 225 | IPR011337 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mismatch repair complex | Any complex formed of proteins that act in mismatch repair. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIRRLPEHL | VNRIAAGEVV | ERPASALKEL | VENSIDAGAR | RISVSLSEGG | LSAIDVADDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CGMTPDEIAL | ALERHATSKL | PDDAIEAVTT | LGFRGEALPS | IGSVADLTIE | SRVRGADGWH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRVDHGELVG | EGPAALPPGT | RIRVSNLFAK | VPARRKFLRS | ARAEYAACVD | VIKRLAMARP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIGFTLEHEG | RRAILVAPDE | QRVDRVAALT | DRDLAQNSVA | VDFRREAVSL | TGVAGLPTFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RGVADHQFLF | VNGRPVKDRL | LIGAVRGAYQ | DMLARDRHPV | IALFVELPGD | QVDVNVHPAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TEVRFRDPGL | VRGMIVGGLR | AALDEAGHRS | VQRPSVAALG | NWQAGGLPTA | SSTAPAIPNG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FAFGAAAERS | GQGSVWDRVA | DFAPAPMARA | EPAYSPPPQQ | ASYPMGVARG | QVAATYIVAE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AEDGLVIVDQ | HAAHERLVLE | RMRRAMADGG | VARQALLLPE | VVELDEVGCD | RLETRIAELA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EMGLELERFG | PKAMLVRATP | ALLGQGDVHG | LIVDLADELA | AYDEALSLKE | RLDHVAATMA |
| 550 | 560 | 570 | 580 | 590 | |
| CHGSVRAGRT | LSVAEMNALL | REMEVTPHSG | QCNHGRPTWI | KLGHGDIEKL | FGRK |