A5V1U3

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Roseiflexus sp (strain RS-1)
KEGG Pathway
rrs:RoseRS_4515
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

666-726 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5V1U3

Entry ID Method Resolution Chain Position Source
AF-A5V1U3-F1 Predicted AlphaFoldDB

No variants for A5V1U3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5V1U3

No associated diseases with A5V1U3

10 regional properties for A5V1U3

Type Name Position InterPro Accession
domain BRCT domain 608 - 698 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 462 - 481 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 496 - 515 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 560 - 579 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 423 - 450 IPR004149
domain NAD-dependent DNA ligase, OB-fold 338 - 414 IPR004150
domain NAD-dependent DNA ligase, adenylation 7 - 334 IPR013839
domain NAD-dependent DNA ligase, N-terminal 5 - 464 IPR013840
active_site NAD-dependent DNA ligase, active site 117 - 146 IPR018239
domain DisA/LigA, helix-hairpin-helix motif 526 - 589 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNDHLTRRV EALREQIRYH NYRYYVLDEP VISDAEYDAL MRELRALEAA HPELVTPDSP
70 80 90 100 110 120
TQRVGAPPGE QFAKVQHVVP MLSLANASDE AEVRAWYDRV VRLLGNDARV AFVVEPKIDG
130 140 150 160 170 180
LAVTLIYRNG ILVRGATRGD GETGEDVTAN LRTIPGIPLR LGAFASNPEG QTNGAPVQAV
190 200 210 220 230 240
IPPLIEVRGE VYMRIADFLR LNEQLAASGE KVAANPRNAA AGSLRQKDPA ITARRPLRFF
250 260 270 280 290 300
AYGIGQIEGV QVQTQWETLN LLRTLGFPVN RDARRFERLD DALAYCREWM TRRDELEYEV
310 320 330 340 350 360
DGVVIKIDSL AQQAQLGVVG RDPRWAIAFK FPAREAVSRL IDIVVNVGRT GVITPNAVIE
370 380 390 400 410 420
PVNIGGVTVR NASLHNADYI AERDIRIGDY VIVKRAGDVI PYIVGPIVAR RDGSERPWQM
430 440 450 460 470 480
PATCPACGTP LERAEGEVAY RCPNFGICPA QITRRIEHFV SRGAMDIAGI GEKQVQLFVE
490 500 510 520 530 540
RGWVQDVADL YTLTPDHFAN VEGYGPKRVA NLLSAIAGSK NRPLHRLIVG LGIRYVGEVV
550 560 570 580 590 600
AQILADHFGS LDALAAASAD EIDALEGIGP AIAASVAAYF ARPESKALIA KLKRAGVRTE
610 620 630 640 650 660
AQETARASRG NALAGKTFVI TGTLPSMSRE EASALITAHG GKVSGSVSKK TDYLVIGAEP
670 680 690 700 710 720
GGTKFAKAQE LGIPMIDEAG LLALIGSGRT ADDQATPASD RRAATASVPP SDDAPGSPRQ
LDFDLT