A5UY81

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Roseiflexus sp (strain RS-1)
KEGG Pathway
rrs:RoseRS_3223
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-531 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5UY81

Entry ID Method Resolution Chain Position Source
AF-A5UY81-F1 Predicted AlphaFoldDB

No variants for A5UY81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5UY81

No associated diseases with A5UY81

4 regional properties for A5UY81

Type Name Position InterPro Accession
domain DHHA1 domain 759 - 899 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 658 - 723 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 9 - 559 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 736 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKLSSAAIR EQFLRFFEER GHVRVPSSSL IPGNDPTLLF TNSGMVQFKD TFLGLEQRPY
70 80 90 100 110 120
TRATTVQKCL RVSGKHNDLE EVGPSPRHHT FFEMLGNFSF GDYFKSEAIP MAWELLTKVF
130 140 150 160 170 180
ELPVERLWFT VFEGDDEVPP DDEAAQLWVA AGADPDRVLR FGRKDNFWVM ADTGPCGPCS
190 200 210 220 230 240
EITIYIGDDL RAMSAQGVNS DDPNYVEIWN NVFMQFERST MQPLHRPSVD TGMGLERMAM
250 260 270 280 290 300
VMQGVHSTYE TDLFIPLIER QLALLGADES TYRARVAPYR AVADHSRAVA FLIADGVLPG
310 320 330 340 350 360
NTGRSYVLRR ILRRAVYQGR TVGFEKPFLA EIVAAVIEQM GAVYPELRER ADFILETVDL
370 380 390 400 410 420
EERQFLRTLS GGMSILNSVI ERVRASGSTV IPGDDAFTLK DTYGFPLDLT QKIAAEHGLT
430 440 450 460 470 480
VDEAGYERRM EEQRDRGRRA AQFKRAAEAE VWAGIDLPPT RFTGYAAVSG SGVVQAIVVA
490 500 510 520 530 540
GDQVAEASAG QQVQIALDST PFYAESGGQV GDTGVLIGPR GRVRVEDVQR PVPGVIVHYG
550 560 570 580 590 600
VVESGSVMLH DPVDAHVDSG RRAAIMRNHT ATHLLHRALR DVLGEHAAQA GSLVAPDRLR
610 620 630 640 650 660
FDFTHTRPLT PEQLHEIERR VNAWIRADTP VVWQELSYQA AIEAGAIALF GEKYGDVVRM
670 680 690 700 710 720
VTIGCVNGHD APSPAALAER ELAGFPMCSR ELCGGTHVGR SGEIGLFRII SESSVAAGVR
730 740 750 760 770 780
RIEALTGPEA EAWVDAQIAT LQAVAARVGA PQTQLVERVE ALIAELKQRQ RALDELTARM
790 800 810 820 830 840
ARSNLEGLLA SVQSVGDIRF LAAQVEAPNA ARLREMGDWL RDKLGSGVVV LATVFDGKAQ
850 860 870 880 890 900
ILAMATPDLA GKRIHAGNLV KALAPIVGGS GGGRPDMAQA GGRDSAKIPQ ALEHVAAVIA
AQAGV