A5UMJ1
Gene name |
thrS |
Protein name |
Threonine--tRNA ligase |
Names |
Threonyl-tRNA synthetase, ThrRS |
Species |
Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) |
KEGG Pathway |
msi:Msm_1214 |
EC number |
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5UMJ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5UMJ1-F1 | Predicted | AlphaFoldDB |
No variants for A5UMJ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5UMJ1 | |||||
No associated diseases with A5UMJ1
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.3 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
| tRNA binding | Binding to a transfer RNA. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| threonyl-tRNA aminoacylation | The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRILLIHSDY | LNYNVKNKTP | VAEEIEDAKK | QGAFDESLVV | FTAVEKDDEN | NPQGIVKNLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEVIKTNDQV | KAENIVLYPY | AHLSSSLSSP | KVAVQVLKDA | EEALDAEGLN | VKRVPFGWYK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFEISCKGHP | LSELSRTITA | EEEEEEEVEK | KPSSWSILDG | DKIIDIDDFK | FENDQLEKLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYELGTGASD | AGEPPHVKLM | REKELCDYES | ASDVGNLKWF | PKGRLVRDLL | ADYVYNLVVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QGAMPIETPI | FYDLDNEAIN | VHAAKFGERQ | YRTDTKKNLM | LRFACCFGAF | RVMADPFITW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KNLPAKLYEL | STYSFRFEKK | GEVVGLKRLR | AFTMPDFHSF | CADMNSTLEE | FSKQTDMCIQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TGVDLDVNYE | IIFRATKDFY | DENKDWMYSI | GKKIGKPVLL | EILPERKHYW | SCKIDFAAID |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLGRPIENPT | VQIDVESGKR | FDITYLGEDG | KEHYPTILHC | SPTGSIERVI | CSLLEKTAIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LDEKAPMLPT | WLSPIEVRII | TVGEDHKDFA | NELYDKINAE | NIRVDVDDRD | ESVGKKIRNA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ATEWIPYIFV | VGDNEKESGV | FSVTVRETGE | KVDMTVDELI | KEILDKTKGM | PYRGLPLPKD |
| ISTRINFQ |