A5UHW6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Haemophilus influenzae (strain PittGG)
KEGG Pathway
hiq:CGSHiGG_07565
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5UHW6

Entry ID Method Resolution Chain Position Source
AF-A5UHW6-F1 Predicted AlphaFoldDB

No variants for A5UHW6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5UHW6

No associated diseases with A5UHW6

4 regional properties for A5UHW6

Type Name Position InterPro Accession
domain DHHA1 domain 732 - 870 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 652 - 695 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 555 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 708 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTTAEIRQS FLDFFHSKGH QVVESSSLVP ENDPTLLFTN AGMNQFKDVF LGMDKRPYSR
70 80 90 100 110 120
ATTAQRCVRA GGKHNDLENV GYTARHHTFF EMLGNFSFGD YFKQDAINFA WEYLTSPQWL
130 140 150 160 170 180
GLPKEKLWVT VYETDDEAYN IWNKEVGVPA ERIIRIGDNK GSPYASDNFW AMGDTGPCGP
190 200 210 220 230 240
CTEIFYDHGD HIWGGPPGSP EEDGDRYIEI WNVVFMQFNR LADGTMEKLP RPSVDTGMGL
250 260 270 280 290 300
ERISAVLQHV NSNYEIDIFK TLIAKTAEIV GATDLTNKSL RVIADHIRSC AYLIADGVIP
310 320 330 340 350 360
SNEGRGYVLR RIIRRAVRHG HLLGAKESFF YKLVPTLIEV MAEAGKDVKA KQTNVEKLLR
370 380 390 400 410 420
LEEEQFARTL ERGLSLLDEA LSQVKDGILS GEVAFKLYDT YGFPLDLTAD VCRERNITID
430 440 450 460 470 480
EQAFDREMEA QRTRAQAASQ FGVDYNSVIR VDGETKFEGY TEVESQAKIT ALFYDGKSVE
490 500 510 520 530 540
SIEAGQSAVV ILENTPFYAE SGGQIGDSGY LSTQGVTFNV KDTQKYGQVF GHIGELTQGS
550 560 570 580 590 600
LKVGQSVNAI VDAKRRHNTS LNHSATHLLH AALRQILGLH VVQKGSLVSD KALRFDFAQP
610 620 630 640 650 660
EAITKEQLSE IETLVNQKIR ANFPVQTDIM DIDSAKAKGA MALFGEKYGD KVRVLTMGDF
670 680 690 700 710 720
SIELCGGIHA KRTGDIGLFK IITENAVAAG IRRIEAVTGQ NAIDWLHNQQ RILTQSADLL
730 740 750 760 770 780
KSDVNTLAEK IQQLQDKTKK VEKELQGLKE KAAMQAGSDF VKSAVKINGV SVIAQQLDGI
790 800 810 820 830 840
ETKSLRVMVD DLKNQLGSGV IAFASILDKK VNLVVGVTND LTAKIKAGEL VNLMAQQVGG
850 860 870
KGGGRPDMAM AGGSQPENVA QAIKVAQDWL NKNL