A5U127

PR
Gene name
mscL
Protein name
Large-conductance mechanosensitive channel
Names
Species
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
KEGG Pathway
mra:MRA_0992
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5U127

Entry ID Method Resolution Chain Position Source
AF-A5U127-F1 Predicted AlphaFoldDB

No variants for A5U127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5U127

No associated diseases with A5U127

1 regional properties for A5U127

Type Name Position InterPro Accession
conserved_site Large-conductance mechanosensitive channel, conserved site 11 - 24 IPR019823

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKGFKEFLA RGNIVDLAVA VVIGTAFTAL VTKFTDSIIT PLINRIGVNA QSDVGILRIG
70 80 90 100 110 120
IGGGQTIDLN VLLSAAINFF LIAFAVYFLV VLPYNTLRKK GEVEQPGDTQ VVLLTEIRDL
130 140 150
LAQTNGDSPG RHGGRGTPSP TDGPRASTES Q