Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A5PK43

Entry ID Method Resolution Chain Position Source
AF-A5PK43-F1 Predicted AlphaFoldDB

54 variants for A5PK43

Variant ID(s) Position Change Description Diseaes Association Provenance
rs434457408 59 S>P No EVA
rs453057478 64 N>T No EVA
rs471406560 67 N>T No EVA
rs432291983 71 D>V No EVA
rs457083021 73 F>S No EVA
rs475459818 74 L>R No EVA
rs440467676 78 Q>H No EVA
rs473527842 78 Q>P No EVA
rs459131629 81 N>T No EVA
rs477589881 82 S>L No EVA
rs444607201 83 L>F No EVA
rs463255359 84 P>L No EVA
rs448814789 87 V>A No EVA
rs1116612318 115 R>Q No EVA
rs476937060 117 V>A No EVA
rs450495150 128 T>P No EVA
rs443960217 138 V>L No EVA
rs481151967 143 K>R No EVA
rs448285377 146 H>N No EVA
rs460278621 146 H>Q No EVA
rs445950077 162 Q>P No EVA
rs464414498 163 V>A No EVA
rs474099806 210 W>G No EVA
rs441209440 233 L>R No EVA
rs459568977 237 K>M No EVA
rs449436261 242 K>Q No EVA
rs468061891 251 T>P No EVA
rs133187160 261 G>S No EVA
rs451431275 276 T>A No EVA
rs451431275 276 T>P No EVA
rs476301867 277 H>P No EVA
rs437002423 281 P>T No EVA
rs455491335 297 M>L No EVA
rs474145799 299 W>G No EVA
rs471616148 303 Q>H No EVA
rs459630785 303 Q>P No EVA
rs438711692 307 M>L No EVA
rs463707734 311 L>P No EVA
rs482334241 318 T>S No EVA
rs444885630 321 Q>E No EVA
rs482026035 322 Y>S No EVA
rs448963966 324 L>M No EVA
rs467391638 325 A>E No EVA
rs434565604 326 Q>P No EVA
rs526140605 328 R>G No EVA
rs518189339 328 R>P No EVA
rs452952581 334 F>L No EVA
rs465131281 335 H>Q No EVA
rs432228573 338 V>A No EVA
rs457315778 339 L>H No EVA
rs442754800 342 Q>H No EVA
rs1117677542 368 V>I No EVA
rs481869052 408 I>L No EVA
rs109619550 412 A>T No EVA

No associated diseases with A5PK43

4 regional properties for A5PK43

Type Name Position InterPro Accession
domain K Homology domain, type 2 378 - 432 IPR004044
domain Small GTP-binding protein domain 115 - 242 IPR005225
domain GTP binding domain 115 - 237 IPR006073
domain Era-type guanine nucleotide-binding (G) domain 111 - 330 IPR030388

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion matrix
  • Mitochondrion inner membrane ; Peripheral membrane protein
  • Localizes on the matrix side on the mitochondrial inner membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
ribosomal small subunit binding Binding to a small ribosomal subunit.
rRNA binding Binding to a ribosomal RNA.

1 GO annotations of biological process

Name Definition
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAASSWRGAV LLRTVSGLWQ AGPDAAREWM TRLPSLLGFQ QRCVSCVAGP AFSGPRLASA
70 80 90 100 110 120
SRPNGQNSAL DCFLGLSQPD NSLPFRVPAV SVHRDEQDLL LVHRPDMPEN PRVLRVVLLG
130 140 150 160 170 180
APNAGKSTLS NQLLGRKVFP VSKKVHTTRS QALGVITEKE TQVILLDTPG LISPAKQKRH
190 200 210 220 230 240
HLELSLLEDP WKSMESADLV VVLVDVSDKW TRNQLSPQVL RCLTQFSQVP SILVMNKVDC
250 260 270 280 290 300
LKQKSVLLEL TAALTEGVVN GKKLKTKQAL RSRPDTHCPS PAAQGPNPQP VRDPQQMGWP
310 320 330 340 350 360
HFQEIFMLSA LSQEDVKTLK QYLLAQARPG PWEFHSEVLT SQTPEEICAN MIREKLLEYL
370 380 390 400 410 420
PEEVPYNVQQ KTVVWDEGPS GELVIEQKLL VSKESHMKIL IGPKGYLIAQ IAQEVGRDLM
430
NIFLCEVQLR LSVKLLK