A5PK19
PR
Gene name |
METTL13 |
Protein name |
eEF1A lysine and N-terminal methyltransferase |
Names |
eEF1A-KNMT, Methyltransferase-like protein 13 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:538472 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5PK19
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5PK19-F1 | Predicted | AlphaFoldDB |
115 variants for A5PK19
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs443080884 | 16 | Y>S | No | EVA | |
| rs456804229 | 23 | Q>H | No | EVA | |
| rs433268987 | 29 | F>L | No | EVA | |
| rs476930460 | 31 | W>R | No | EVA | |
| rs438815976 | 40 | G>W | No | EVA | |
| rs479112426 | 48 | P>T | No | EVA | |
| rs461117185 | 49 | R>S | No | EVA | |
| rs481298748 | 50 | E>Q | No | EVA | |
| rs444035091 | 52 | V>G | No | EVA | |
| rs475732698 | 52 | V>M | No | EVA | |
| rs440103641 | 53 | L>R | No | EVA | |
| rs477855399 | 53 | L>V | No | EVA | |
| rs459866416 | 54 | V>G | No | EVA | |
| rs480028595 | 57 | C>G | No | EVA | |
| rs448613672 | 57 | C>W | No | EVA | |
| rs450750502 | 60 | S>* | No | EVA | |
| rs482369639 | 60 | S>P | No | EVA | |
| rs464403922 | 61 | E>* | No | EVA | |
| rs433240174 | 61 | E>A | No | EVA | |
| rs453404701 | 61 | E>D | No | EVA | |
| rs467068610 | 63 | S>R | No | EVA | |
| rs3423649349 | 63 | S>T | No | EVA | |
| rs521816765 | 90 | R>C | No | EVA | |
| rs435359666 | 118 | V>A | No | EVA | |
| rs526558472 | 131 | E>K | No | EVA | |
| rs876442452 | 139 | V>G | No | EVA | |
| rs876156092 | 146 | V>G | No | EVA | |
| rs876450144 | 149 | V>G | No | EVA | |
| rs455568873 | 150 | L>M | No | EVA | |
| rs475695972 | 152 | V>G | No | EVA | |
| rs444353887 | 156 | Y>* | No | EVA | |
| rs451282158 | 168 | K>T | No | EVA | |
| rs797353883 | 176 | R>Q | No | EVA | |
| rs440021018 | 177 | E>A | No | EVA | |
| rs440021018 | 177 | E>G | No | EVA | |
| rs460233299 | 179 | W>G | No | EVA | |
| rs473947200 | 187 | A>D | No | EVA | |
| rs462184427 | 191 | D>G | No | EVA | |
| rs442202350 | 191 | D>N | No | EVA | |
| rs451117159 | 194 | L>W | No | EVA | |
| rs457954539 | 195 | E>D | No | EVA | |
| rs446840273 | 205 | F>V | No | EVA | |
| rs467080418 | 209 | M>I | No | EVA | |
| rs435730077 | 214 | P>R | No | EVA | |
| rs109431475 | 215 | V>F | No | EVA | |
| rs469185818 | 216 | T>P | No | EVA | |
| rs451596628 | 223 | F>L | No | EVA | |
| rs471707054 | 230 | Q>R | No | EVA | |
| rs453688239 | 234 | V>G | No | EVA | |
| rs135778370 | 248 | E>G | No | EVA | |
| rs442485662 | 253 | A>G | No | EVA | |
| rs475834558 | 260 | Y>S | No | EVA | |
| rs444630517 | 261 | R>L | No | EVA | |
| rs478587192 | 264 | G>R | No | EVA | |
| rs446831652 | 267 | S>R | No | EVA | |
| rs460505559 | 268 | V>E | No | EVA | |
| rs460505559 | 268 | V>G | No | EVA | |
| rs480715446 | 269 | S>A | No | EVA | |
| rs469503895 | 271 | D>Y | No | EVA | |
| rs437781696 | 276 | D>A | No | EVA | |
| rs445092926 | 279 | E>A | No | EVA | |
| rs465265150 | 279 | E>D | No | EVA | |
| rs445092926 | 279 | E>G | No | EVA | |
| rs433873154 | 283 | T>P | No | EVA | |
| rs453645015 | 284 | L>H | No | EVA | |
| rs453645015 | 284 | L>R | No | EVA | |
| rs456056044 | 288 | D>G | No | EVA | |
| rs476151347 | 294 | P>T | No | EVA | |
| rs1114787175 | 296 | R>W | No | EVA | |
| rs451856326 | 297 | D>E | No | EVA | |
| rs472079522 | 300 | F>Y | No | EVA | |
| rs453043346 | 305 | I>M | No | EVA | |
| rs474449073 | 310 | E>D | No | EVA | |
| rs456493700 | 312 | E>D | No | EVA | |
| rs436696978 | 312 | E>G | No | EVA | |
| rs476623422 | 313 | W>R | No | EVA | |
| rs473098327 | 315 | F>V | No | EVA | |
| rs458967424 | 332 | R>G | No | EVA | |
| rs440989885 | 346 | G>D | No | EVA | |
| rs481081409 | 347 | M>L | No | EVA | |
| rs449910830 | 347 | M>R | No | EVA | |
| rs463159436 | 348 | D>N | No | EVA | |
| rs463159436 | 348 | D>Y | No | EVA | |
| rs477026006 | 350 | I>F | No | EVA | |
| rs445662749 | 353 | E>A | No | EVA | |
| rs465819692 | 359 | M>V | No | EVA | |
| rs461944894 | 363 | P>L | No | EVA | |
| rs434479486 | 366 | M>I | No | EVA | |
| rs455304829 | 368 | A>S | No | EVA | |
| rs447746998 | 369 | Q>H | No | EVA | |
| rs479919575 | 377 | V>G | No | EVA | |
| rs209639597 | 386 | V>I | No | EVA | |
| rs876180505 | 410 | Y>F | No | EVA | |
| rs876066822 | 453 | T>P | No | EVA | |
| rs444657708 | 464 | S>A | No | EVA | |
| rs451897216 | 476 | K>Q | No | EVA | |
| rs472171636 | 481 | G>S | No | EVA | |
| rs461074531 | 527 | D>G | No | EVA | |
| rs720525515 | 533 | V>E | No | EVA | |
| rs443153498 | 545 | R>L | No | EVA | |
| rs211520609 | 555 | D>Y | No | EVA | |
| rs482342390 | 571 | V>G | No | EVA | |
| rs450873652 | 575 | D>G | No | EVA | |
| rs464699390 | 591 | A>P | No | EVA | |
| rs477988464 | 595 | Q>H | No | EVA | |
| rs467255679 | 611 | F>L | No | EVA | |
| rs465708392 | 650 | L>R | No | EVA | |
| rs433913602 | 652 | C>S | No | EVA | |
| rs432528282 | 652 | C>S | No | EVA | |
| rs454131979 | 655 | H>R | No | EVA | |
| rs474272641 | 662 | T>P | No | EVA | |
| rs442943142 | 667 | E>D | No | EVA | |
| rs456598504 | 675 | T>P | No | EVA | |
| rs476413114 | 678 | K>T | No | EVA | |
| rs458628651 | 697 | K>Q | No | EVA |
No associated diseases with A5PK19
No regional properties for A5PK19
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A5PK19 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| negative regulation of cell cycle G1/S phase transition | Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLLPKSSKE | FGSVDYWEKF | FQQRGKKAFE | WYGTYLELCG | VLHKYIKPRE | KVLVVGCGNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELSEQLYDVG | YQDIVNIDIS | EVVIKQMKER | NASRRPRMSF | LKMDMTQMEF | PDASFQVVLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGTLDAVLTD | EEEKTLQQVD | RMLAEVGRVL | QVGGRYLCIS | LAQAHVLKKA | VGHFSREGWM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRVHQVASSQ | DQLLEAEPRF | SLPVFAFIMT | KFRPVTGSAL | QIFELCAQEQ | GKPVRLESAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLAEAVRERQ | QYAWLCSQLY | RKAGLGSVSL | DLCNGDTGEP | RYTLHVVDSP | TVKPSRDNHF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIFIIPQGRE | TEWLFGMEEG | RKQLAASAGF | RRLITVALHR | GQQYEGMDSI | QAELSARVME |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAPAGMPAQL | QVPFLSVGGD | IGVRIVQHQA | CSPLSGDYVI | EDVQGDDKRY | FRRLIFLSNR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NVVQSEARLL | QDVSHRAQKK | RKKDRKKHRP | ADTPEDLPAA | QGQSIDKSYL | CCEHHKAMIA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLALLKNPEL | LLETPLALLV | VGLGGGSLPL | FIHDHFPKSC | IHAVEIDPSM | LEVATQWFGF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SQSDRMKVHI | ADGLDFITRL | AEEEARPHYD | VIMFDVDSKD | PTLGMSCPPP | AFVAQLFLQK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VKSILTPEGV | FILNLVCRDL | GLKDSVLAGL | KAVFPLLYVR | RIEGEVNEIL | FCQLHSECKL |
| 670 | 680 | 690 | |||
| ATPELLEMAR | ALEQTLRKPG | KGWDDTYVLS | DMLNTVKIV |