A5IMH8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)
KEGG Pathway
tpt:Tpet_1387
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

136-211 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5IMH8

Entry ID Method Resolution Chain Position Source
AF-A5IMH8-F1 Predicted AlphaFoldDB

No variants for A5IMH8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5IMH8

No associated diseases with A5IMH8

4 regional properties for A5IMH8

Type Name Position InterPro Accession
domain DHHA1 domain 732 - 862 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYMTSEEIR EAFLKFFEKK GHKILPSASL IPDDPQLLFT VAGMVPFKPI FWGKVEPVYT
70 80 90 100 110 120
RVATCQKCLR TVDIENVGKT PRHHTFFEML GNFSFGDYFK EEAIEWAWEF LTQVLGVPEE
130 140 150 160 170 180
KLWVSVYEED EEAFRIWNEK IGLPEKKILR MGKEDNFWGP AGPTGPCGPD TEIFYDTGYS
190 200 210 220 230 240
KGCPEGEECT PANSEGRFVE IWNLVFTEYY QDEEGKLHPL PRKNIDTGAG LERFCAMMQG
250 260 270 280 290 300
VYSNFDTDLF QPIINRIEEL TGVGYKTDEE KDVSIRVIAD HMRAITFLIS EGVFPSNEGR
310 320 330 340 350 360
GYVLRRIIRR AMRHGILLGM SEPFLYRIVD AVAEKMGKVY PEIVRGESMV KEVLSAEESR
370 380 390 400 410 420
FLKTLEQGMK VFDEIVEKKG RIDSEDAFKL YDTYGLPLEL TLEIAREKGV EVDVKEFNKY
430 440 450 460 470 480
MEEQQRKSRV ALGDVEFARR YEYLEELPKD FRTEFTGYEK LEDEGEVVLI AKNEKAVEDA
490 500 510 520 530 540
TEDAVEVVFS KTPFYAEKGG QVSDTGTVEW EDGKALVEYV FEASEGVIVH RIKVLAGTLR
550 560 570 580 590 600
RGQKVVLRVD KKRREATMRN HTATHLLHAA LKKVLGDHVR QAGSLVAPDR LRFDFTHFKG
610 620 630 640 650 660
LSMAEIEQVE NLVNEWIMEA IPVEVRYTSY EEAVKSGVVA LFTEKYGDVV RVVEVPGVSK
670 680 690 700 710 720
ELCGGTHVSN TGQIGLFKII SEESVSSGVR RIEAVTGFST LELLRNQKKL IDQLKEILGA
730 740 750 760 770 780
REDELTDRVL GLREKVKELE KKLSQGRISE EKIAMKQLED GARVFYAVFE DVEAKHLGGI
790 800 810 820 830 840
ADNVLKKERE GIVILLSKFE DKVSLVVKVS ENLLDKYDAS SIARNIAKEL GGSGGGRRNF
850 860
AQAGGRHPEK IRGVLERLEE FLR