A5IME8

PR
Gene name
rsmA
Protein name
Ribosomal RNA small subunit methyltransferase A
Names
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Species
Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)
KEGG Pathway
tpt:Tpet_1357
EC number
2.1.1.182: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

183-256 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5IME8

Entry ID Method Resolution Chain Position Source
AF-A5IME8-F1 Predicted AlphaFoldDB

No variants for A5IME8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5IME8

No associated diseases with A5IME8

2 regional properties for A5IME8

Type Name Position InterPro Accession
domain RsgA GTPase domain 85 - 258 IPR010914
domain Circularly permuted (CP)-type guanine nucleotide-binding (G) domain 101 - 256 IPR030378

Functions

Description
EC Number 2.1.1.182 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTSDYLKKY GVKLKKHLGQ VFLSDDRIAK RIVKEVGLTP EDVVVEIGAG AGTLTEELAK
70 80 90 100 110 120
TGARVIAYEI DESLAPVLRE RLSKYPNVEL RFEDFLKAKD IPEGAICVSN IPYSITGPIM
130 140 150 160 170 180
EKIIEWKFKR AIVMVQKEVG ERILAKPGKK TYGYLSVVVQ TFYEVKKLFD VSRSCFVPNP
190 200 210 220 230 240
EVDSTVVDLR RKSVDLDFEK FRKFVSMIFA KKRKTLKNNL RPFLSVFEGV DLSRRAEQLT
250
VEEIVEFYEK WRRALECSKE