A5IBP1
Gene name |
tmk |
Protein name |
Thymidylate kinase |
Names |
dTMP kinase |
Species |
Legionella pneumophila (strain Corby) |
KEGG Pathway |
lpc:LPC_0815 |
EC number |
2.7.4.9: Phosphotransferases with a phosphate group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5IBP1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5IBP1-F1 | Predicted | AlphaFoldDB |
No variants for A5IBP1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5IBP1 | |||||
No associated diseases with A5IBP1
9 regional properties for A5IBP1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Oxidoreductase FAD/NAD(P)-binding | 181 - 288 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 96 - 103 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 128 - 137 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 180 - 199 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 218 - 229 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 250 - 266 | IPR001709-5 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 274 - 282 | IPR001709-6 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | 50 - 155 | IPR008333 |
| domain | FAD-binding domain, ferredoxin reductase-type | 44 - 156 | IPR017927 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.4.9 | Phosphotransferases with a phosphate group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| thymidylate kinase activity | Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dTDP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). |
| dTTP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLTGKLIV | IEGLEGAGKS | TAVNLVVELL | SQKKISTITT | REPGGTRIGE | ILRSIIKNPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YNNVLDDRSE | LLLLYAARIQ | LIEQVIKPAL | NEGQWVIADR | FELSTLAYQG | GGRKMDMRVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NELSNFCLKG | FKPDLTLYLD | INPELGMIRA | KSRGKFDRIE | QESIEFFHRI | HDTYHILVKQ |
| 190 | 200 | 210 | |||
| NPEIMMIDAN | RPLEDVQSSI | QSVIEEFIEH | NL |