A5GEV5

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens)
KEGG Pathway
gur:Gura_1770
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

309-420 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5GEV5

Entry ID Method Resolution Chain Position Source
AF-A5GEV5-F1 Predicted AlphaFoldDB

No variants for A5GEV5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5GEV5

No associated diseases with A5GEV5

4 regional properties for A5GEV5

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 24 - 87 IPR003594
domain DNA mismatch repair protein, S5 domain 2-like 209 - 327 IPR013507
conserved_site DNA mismatch repair, conserved site 95 - 101 IPR014762
domain MutL, C-terminal, dimerisation 415 - 560 IPR014790

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATRIKILPE NLTNKIAAGE VVERPASVVK ELVENALDAG CSEVVVEIEA GGRRLIKVTD
70 80 90 100 110 120
SGCGMTREDA LLALERHATS KIASDSDLFG LATLGFRGEA LPSIASVSRF ALATREKGAI
130 140 150 160 170 180
EGTEIYAEGG RVKEVKVCGM AEGTVISVRN LFFNTPARLK FMKSSDTEAG HVGDLLTKLA
190 200 210 220 230 240
ISRPDVRFIY NNDGRTIFRA LDADLRERVA TLLGRALSAD LYPLDFHDGP LGVTGLIAKP
250 260 270 280 290 300
ECSRSAASHL YTYINGRFIK DKVVQHAVLQ AYRNFMERGR YPVVVLFITV PADEVDVNVH
310 320 330 340 350 360
PTKHEVRFRE QGRVHDAIQA ALESVLRATP WVRKQAAPQP FASPPPASEA SATRVAEVRE
370 380 390 400 410 420
TLARYSPEKH LQQSFTVPPA ATFQRQQGAV SLPVAAREDD TASDKTESKG YYCSLSVIGQ
430 440 450 460 470 480
FNAAYILCQD GTDLVIIDQH AAHERVAFEK LKAQFAAAQV ESQRLLFPET IELSFKEGAT
490 500 510 520 530 540
LREHLAELGR LGFSLEEFGG ATWLLNAVPR LLSGTDYLRT LRDILEELQT LGRSRTFADA
550 560 570 580 590 600
LEEILSRIAC HSVVRGIHPL NGQEISALFA QMDATEFSSN CPHGRPVLRS LTLPEIERMF
KR