A5GD98

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens)
KEGG Pathway
gur:Gura_0222
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

818-876 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5GD98

Entry ID Method Resolution Chain Position Source
AF-A5GD98-F1 Predicted AlphaFoldDB

No variants for A5GD98

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5GD98

No associated diseases with A5GD98

4 regional properties for A5GD98

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 874 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGKEIRAQF FKFFEERGHT VVESSNLIPR NDPTLLFTNA GMNQFKDVFL GLEKRDYVRA
70 80 90 100 110 120
CSSQKCVRAG GKHNDLENVG RTARHHTFFE MLGNFSFGDY FKKEAIAFAW EFLTKELKLD
130 140 150 160 170 180
KDRLYVTVYT DDDEAADIWN RQEGVPLERI YRFGEKDNFW SMGDTGPCGP CTEIFWDNGP
190 200 210 220 230 240
GTGCGSPTCE VGCDCDRYME IWNNVFMQFN RDAQGNLTPL PKPSVDTGMG LERISTVMQG
250 260 270 280 290 300
VTSNYDTDLL QGIIKHVEKL SGKRYRQDER DDVSMRVIAD HSRAITFLIC DGILPSNEGR
310 320 330 340 350 360
GYVLRRIMRR AARHAKMLGF AEPALYRIVD AVNTMMGDAY PELLEREEYI KKVIHAEEER
370 380 390 400 410 420
FIETLDRGLA ILNEEVAALK KEGKSVVPGE VIFKLYDTYG FPVDLTADIV ENEGFTIDED
430 440 450 460 470 480
GFALCMERQR LQARENWKGS GEEGLAEIYK TLHGRGIRSA FVGYSEQTAY SAITAILREG
490 500 510 520 530 540
AEVAEAVAGE MVEVVVDTTP FYGASGGQAG DTGVISTGSA HLRVVATSKP FPDLTVHRAL
550 560 570 580 590 600
VTEGTVKAGD AADLRVATEV RGATARNHTA THLLQSALRQ VLGEHVKQAG SLVTAERLRF
610 620 630 640 650 660
DFTHFSAMTV EELRRVENIV NTYVMDNADV KSLEMAATEA MQSGATALFG EKYGDRVRVV
670 680 690 700 710 720
KVGEVSSELC GGTHVRAAGD IGFFKIVGEA GIAAGVRRIE ALTGSGALEY VQQLEDEQRS
730 740 750 760 770 780
IAVLVKAEGG TALDKVDRLL ARQKELQREV EALQARLNAS RSADLLAGAR ETNGIKVLAA
790 800 810 820 830 840
KVEMDDPKGL RELADSLKDR LQSGVIVIGC VSAGKANLLV AVTKDLSDRL RAGDIIKSLA
850 860 870
PIIGGSGGGK PELAQAGGTK PENLDEALEA AYKIIG