A5GA66
Gene name |
metK |
Protein name |
S-adenosylmethionine synthase |
Names |
AdoMet synthase, MAT, Methionine adenosyltransferase |
Species |
Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens) |
KEGG Pathway |
gur:Gura_1332 |
EC number |
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5GA66
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5GA66-F1 | Predicted | AlphaFoldDB |
No variants for A5GA66
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5GA66 | |||||
No associated diseases with A5GA66
5 regional properties for A5GA66
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosylmethionine synthetase, N-terminal | 6 - 103 | IPR022628 |
| domain | S-adenosylmethionine synthetase, central domain | 118 - 235 | IPR022629 |
| domain | S-adenosylmethionine synthetase, C-terminal | 237 - 376 | IPR022630 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 120 - 130 | IPR022631-1 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 263 - 271 | IPR022631-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.6 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| methionine adenosyltransferase activity | Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| S-adenosylmethionine biosynthetic process | The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMKDFIFTS | ESVSEGHPDK | VADQVSDAIL | DAILTQDPKS | RVACETLVTT | GMTVVAGEIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNAIVDYPKI | VRETIKEIGY | NDSAMGFDWE | TCAVLTSIDK | QSPDIAQGVT | EGEGLFKEQG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGDQGLMFGY | ACNETPELMP | MSILLSHKLV | KKLADVRKSG | VLDFLRPDSK | SQVSIQYIND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPVHVDTVVI | SSQHTPEVSY | ETIKEGIIEE | VVKKIIPEEL | MDAKTRFLIN | PTGRFVIGGP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGDCGLTGRK | IIVDSYGGHG | AHGGGAFSGK | DPSKVDRSAA | YMGRYVAKNL | VAAGLCEKCE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VQVAYAIGVA | EPVSVMVDTS | GTGKIPSARI | AQIVREVFDL | RPRAIIEQLD | LLRPIYKKTA |
| 370 | 380 | ||||
| AYGHFGRELP | EFTWERTDKV | SIIREKAGI |