A5G1Y4

PR
Gene name
gltX2
Protein name
Glutamate--tRNA ligase 2
Names
Glutamyl-tRNA synthetase 2, GluRS 2
Species
Acidiphilium cryptum (strain JF-5)
KEGG Pathway
acr:Acry_2675
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

73-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5G1Y4

Entry ID Method Resolution Chain Position Source
AF-A5G1Y4-F1 Predicted AlphaFoldDB

No variants for A5G1Y4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5G1Y4

No associated diseases with A5G1Y4

3 regional properties for A5G1Y4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 8 - 19 IPR001412
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 2 - 306 IPR020058
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 365 - 442 IPR045462

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVKFRFAPSP TGHLHAGNAR LAVVNALAAR AMGGTLLLRI DDTDRERSKP EYEAGIEQDL
70 80 90 100 110 120
RWLGIGWDEM ARQSDRMDRY AAAAERLKAA GLLYPCFESE EELAAKRALR AKRHLPPVYD
130 140 150 160 170 180
RAMLSLTAEQ RAAAEAGGKR PYFRFKLSDG AVAWNDLVLG RREVALGTVS DPVLIRADGT
190 200 210 220 230 240
PLYTFTSVVD DLELGVTHVV RGEDHVTNTA VQIDLMRALE PRRAVPAFGH LPLISDVTGE
250 260 270 280 290 300
KLSKRAGSVS VRQFRRDGIE AMALVSYLAR LGSRRDPEPL TLEELAGTFD LGDFSRGAPR
310 320 330 340 350 360
FDPKQLLALN RRVLHGLPFE AVAERLPEGC GAEFWMAVRG NLDLLSEARL WWEVVSGEIE
370 380 390 400 410 420
TPSLPEAASL LRAALEALPP EPWDETTWKG WTGAVAAASG ARGKALYLPL RLALTGESHG
430 440
PELAALLPLI GRARAAARLE RAAG