A5F2P8

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
KEGG Pathway
vcr:VC395_1050
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

521-594 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5F2P8

Entry ID Method Resolution Chain Position Source
AF-A5F2P8-F1 Predicted AlphaFoldDB

No variants for A5F2P8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5F2P8

No associated diseases with A5F2P8

7 regional properties for A5F2P8

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 15 - 26 IPR001412
domain tRNA-binding domain 582 - 683 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 542 - 683 IPR004495
domain Methionyl/Leucyl tRNA synthetase 9 - 396 IPR015413
domain Methioninyl-tRNA synthetase core domain 7 - 371 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 384 - 395 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 374 - 541 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANDPRKLLV TCALPYANGS IHLGHMLEHI QADIWVRYQR LRGNTVNFIC ADDAHGTPIM
70 80 90 100 110 120
LKAQQMGMTP EAMIEMVSEE HQRDFAGFDI SFDNYHSTHS DENRELASHI YLQLKKNGFI
130 140 150 160 170 180
SSRTISQLFD PEKEMFLPDR FVKGTCPKCK SEDQYGDNCD ACGETYSPTE LINPKSAVSG
190 200 210 220 230 240
ATPVMKDSEH FFFDLPQFES MLKEWTRSGS LQSETANKMQ EWFEGGLQQW DISRDAPYFG
250 260 270 280 290 300
FEIPGEKDKF FYVWLDAPIG YMGSFKNLCD KRGDLNFNEY WNKDSKTELY HFIGKDIVYF
310 320 330 340 350 360
HSLFWPAMLD GSGFRKPTNV FVHGYVTVNG AKMSKSKGTF VKASTYLNHL DPECLRYYYA
370 380 390 400 410 420
AKLNNRIDDL DLNLEDFTQR VNADVVNKIV NLASRNAGFI TKRFDGKLSA HFAEPELYAE
430 440 450 460 470 480
FAGAADRIAE LFEAREFGRA IREITALADK ANQYVDEKAP WVVAKQEGQD QALQDICTVG
490 500 510 520 530 540
INLFRILMTY LKPVMPALAE RTEAFLNQEL TWEGVATPLT DHAVTPFKAL FNRIDPKQVE
550 560 570 580 590 600
AMIEASKAEA AAEKAAADAA KPKSAETELS KDPLAAEIEF DDFAKVDLRI AKILSCEAVE
610 620 630 640 650 660
KSDKLLKFEL DIGGETRQVF SGIKSAYQPE DLIGKYTVVV ANLKPRKMKF GMSEGMILAA
670 680
GPGGSDLWLL EPHQGAQAGM RVM