A5E450

PR
Gene name
LELG_04389
Protein name
Lipoyl synthase, mitochondrial
Names
Lipoate synthase, LS, Lip-syn, Lipoic acid synthase
Species
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
KEGG Pathway
lel:LELG_04389
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5E450

Entry ID Method Resolution Chain Position Source
AF-A5E450-F1 Predicted AlphaFoldDB

No variants for A5E450

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5E450

No associated diseases with A5E450

3 regional properties for A5E450

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 170 - 379 IPR006638
domain Radical SAM 165 - 384 IPR007197
domain Lipoyl synthase, N-terminal 71 - 155 IPR031691

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPRSINILK LRPTTQVTTT ALRALATEAK TTLGATPGST STSTSTSTAT TTTLESTSTS
70 80 90 100 110 120
TSGDATETTI KETKSIKRKR TFFTDELNKG PSFDDFVSGK AKDMLEDPLE LARKDPNAKL
130 140 150 160 170 180
PLWLKVPIPK GKSFHNVKND VRELKLSTVC EEAKCPNIGE CWGGKKSEAT ATIMLLGDTC
190 200 210 220 230 240
TRGCRFCSVK TNRKPGKPDP MEPENTAEAI SRWGLGYVVL TTVDRDDLID GGANHLKETV
250 260 270 280 290 300
QKIKFKAPQI LVEVLGGDFR GDLEMVKILA NSGLDVYAHN METVEALTPH IRDRRATYRQ
310 320 330 340 350 360
SLAVLRTAKE TKPSLITKTS LMLGFGETDD QIRQTLKDLR EVGCDVVTFG QYMRPTKRHM
370 380 390 400 410 420
KVVEYVTPEK FDYWRDVALE MGFLYVASGP LVRSSYKAGE AFIENVLKKR KHNVGESPRM
430
LQEVKPSIFK RA