A5E1T3

PR
Gene name
TIF32
Protein name
Eukaryotic translation initiation factor 3 subunit A
Names
eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog
Species
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
KEGG Pathway
lel:LELG_03570
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5E1T3

Entry ID Method Resolution Chain Position Source
AF-A5E1T3-F1 Predicted AlphaFoldDB

No variants for A5E1T3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5E1T3

1 associated diseases with A5E1T3

[MIM: 614850]: Encephalopathy, acute, infection-induced, 6, herpes-specific (IIAE6)

A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269|PubMed:22105173}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Without disease ID
  • A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269|PubMed:22105173}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

6 regional properties for A5E1T3

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 169 - 177 IPR000629
domain Helicase, C-terminal 234 - 395 IPR001650
domain DEAD/DEAH box helicase domain 48 - 211 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 42 - 238 IPR014001
domain RNA helicase, DEAD-box type, Q motif 23 - 51 IPR014014
domain ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain 25 - 224 IPR044728

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPAHKGHAF RPENVLKRAR DLIGVGQKEA ALDTLYELII SKRIRYLQVE DLEPIADLLI
70 80 90 100 110 120
ELAVELRRGK LAKDALHQYK KNIQLNEHGL ESVQTIVRKF ISLAEKKLDE AQAQADIKID
130 140 150 160 170 180
QEEAAEEDLE TAQTPETILL SAVSNTDTAD RTERELVTPW LRFLWEAFRA TLDILRNNSK
190 200 210 220 230 240
LEVTYSAIVN QAFKFCLNFK RKAEFRRLCE LLRVHMQSVT TQTKTSSNNA IDLSDFETVQ
250 260 270 280 290 300
RYLEQRFAQL NIAVKLELWQ ESFRSVDDVH TLITASKKAP KPTMMANYYE NLARIFAVSD
310 320 330 340 350 360
NALFHAAAWN KFFNLYSQSP MATDEELKKY ASVFVLSTLA IPQSAIHDAD EHRTKNSKLS
370 380 390 400 410 420
SLLNLSQPPT KDGLTRSIIT RNVLKYVDEP IRILFELLQG GNFHPLSVKK QVVELFKILQ
430 440 450 460 470 480
ADENFKKYIP TLTEVILLRI FQQVSQVYDV VKLNFLTSLG VFEGLEYTLT ELEVEDLIVN
490 500 510 520 530 540
AVKDDLLALT IDHEAGVVNF KSNPFEETTT SFANDLQISP AELVRSQISK LAATLASSVQ
550 560 570 580 590 600
IIDPSYERRQ QEAKQAALQR AVEGLIREQQ RLADRTKILE ERKLAAEKRK REEEELQAKL
610 620 630 640 650 660
KQERIAAEQK AEQERLIQEQ ERKKEEKLQR EKEAILENEK RKLAEEINAK GIIKVDMNNL
670 680 690 700 710 720
KDLDKSKLQL MQIEQLNKDR KELEEKLKGT AKKADYLERA FRKYELKLLE AEAQKQQGLE
730 740 750 760 770 780
REQYENVKQL KVAKAKKDFD EAIQVRDRLQ RIIPDYTKFK SEIDAKNAVK VAKLKEEAQE
790 800 810 820 830 840
RFEKAKQERI EKVKRQRIEE LKSRKERERK AQAEEAARKA QAAEHAKLKE ELRIQREKDE
850 860 870 880
ELQRKRDEMA AAAAAAQAEQ EAKPPKQMSY SERMRLKREG KLP