A5DWF4

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
KEGG Pathway
lel:LELG_01690
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5DWF4

Entry ID Method Resolution Chain Position Source
AF-A5DWF4-F1 Predicted AlphaFoldDB

No variants for A5DWF4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5DWF4

No associated diseases with A5DWF4

7 regional properties for A5DWF4

Type Name Position InterPro Accession
domain SNF2, N-terminal 420 - 713 IPR000330
domain Bromodomain 1063 - 1173 IPR001487
domain Helicase, C-terminal 737 - 903 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 413 - 602 IPR014001
domain Helicase/SANT-associated domain 256 - 328 IPR014012
conserved_site Bromodomain, conserved site 1089 - 1146 IPR018359
domain Snf2, ATP coupling domain 946 - 1012 IPR029295

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

2 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKKEVSASK PGNTKKDNVL LKKRKQQAVE KEEAEKEKEE GVSEDEFNVQ GLIDPESDSD
70 80 90 100 110 120
DEGAAAAEEE EEEEEQQQDV KELDLDKGEV ISSDSDAEDF DSEEELNKLL GEEDDPSDYS
130 140 150 160 170 180
SVGFSDEPKE DGDEQDEQDA FAAADAATDD DAFGDVKLKN LSITDPSKLE VRTKFSDGTP
190 200 210 220 230 240
RIIKPEIEPV YDSDDSDAEN FNTIGNIPIS AYEEMPHIGY DINGKRIMRP AKGSALDQLL
250 260 270 280 290 300
ESIDLPQGWT GLLDQNTGAP LKITDEELEL IRKIQQQENT DENINPYEPL NDWFTKNQEV
310 320 330 340 350 360
MPLTAVPEPK RRFVPSKHEA KRVMKIVKAI REGRILTPEK AKELKEKETE EMNYDLWQNE
370 380 390 400 410 420
SEVPDHIMNL RAPKLPPPTN EESYNPPEEY LLNEEEKQKW LEQDPVDRER NFIPQKYSSL
430 440 450 460 470 480
RLVPGYQDSV RERFERSLDL YLAPRLRKNK LNIDPESLIP ELPSPKDLRP FPIKCSTVYE
490 500 510 520 530 540
GHTGKIRTLS IDPQGLWLAT GSDDGSVRIW EVLTGRQVFK AQLVNKEHNG EDHIESLEWN
550 560 570 580 590 600
PNAQTGILAV CAGENIYLLV PPIFGFEIEN TGKLRIESGW GYDTFGNTKQ DLKVKGEDTK
610 620 630 640 650 660
GDLDDDEEEE EEEEDDDDDE GQGKVKAHNS TAPAKKDVAK WINPNSSQQA MGISAIIQCR
670 680 690 700 710 720
RTVKKISWHR KGDYFVTVSP DSKNTAVLIH QLSKHLSQSP FRKSKGVIMD AKFHPFKPQL
730 740 750 760 770 780
FVASQRQIKI YDLAQQTLLK KLLPGVRLLS TIDLHPRGDN LLAASYDKRV LWHDLDLAAT
790 800 810 820 830 840
PYKTLRYHEK AVRQIKYHKG SLPLFASASD DGIIHVFHGT VYDDLMTNPL LVPLKKLSGH
850 860 870
KVINQIGVLD IVWHPKEAWL FSAGADGTAR LWTT