Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A5DUG6

Entry ID Method Resolution Chain Position Source
AF-A5DUG6-F1 Predicted AlphaFoldDB

No variants for A5DUG6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5DUG6

No associated diseases with A5DUG6

No regional properties for A5DUG6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A5DUG6

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Multi-pass membrane protein
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
mitochondrial outer membrane translocase complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.
mitochondrion-endoplasmic reticulum membrane tethering The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYTYMEYLQK CFFKTTNWNE DNIFSNINAT SQAILDFPIP NGLKVDSSSK TTDYLASSFT
70 80 90 100 110 120
LSNFHLINGS LAYLYSLCPL TNTMGTKDVS LQDAIAGFRI IEPMITLRNQ PVGPKTKKLR
130 140 150 160 170 180
YSNKYNNNNN NNKNINNKKY AMKKDSRNSL LYGRMYFPGS ALEAMVIKRI NENTQLLVKC
190 200 210 220 230 240
VSNPHLERNG TMIVYLQNNT MKYLRELIYS TNESLIGLRF LYNLGNPITK NISPALAPKF
250 260 270 280 290 300
DNSVVSVGTE LWFAARTMSP GLSTALRYST RSTSTGKPLT MTLAVNPILG HISSTYTVKT
310 320 330 340 350 360
SVASTFCSKY DFNFFSYASN LSLGFELYSY ARNKNYLSPV ESSMMLEQPT ATVPGSLHNQ
370 380 390 400 410 420
ATKPRRESQR QKSEDYISSS DSDYTRMQVK EFGPGGRITS EQKSNDRLPN KVSPIQNKRD
430 440 450 460 470 480
RGREHFTNSS SNNSNSNINS NANTNLDAAF EEKVTTAFQN LVNASDFSSV VKVSTSLRDK
490 500 510 520
TVKLLWEGRV KDFLVSTGAR IAINPVTNAP EFSKFGINFS YAF