A5DGW8

PR
Gene name
MMM1
Protein name
Maintenance of mitochondrial morphology protein 1
Names
Species
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
KEGG Pathway
pgu:PGUG_02519
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5DGW8

Entry ID Method Resolution Chain Position Source
AF-A5DGW8-F1 Predicted AlphaFoldDB

No variants for A5DGW8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5DGW8

No associated diseases with A5DGW8

2 regional properties for A5DGW8

Type Name Position InterPro Accession
domain C1q domain 819 - 949 IPR001073
domain EMI domain 54 - 132 IPR011489

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

3 GO annotations of biological process

Name Definition
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVLNFYVNP YLNLSFDLLP VANHFCRYSR HWKMSRDITR PDELASLIQL QDRLQTQQDE
70 80 90 100 110 120
LFRKQQELQF RETYAGTGST KSFTQGLIIG QLSVIILLGI FIKFFVFADS STTSSTSGNG
130 140 150 160 170 180
ISSKTDVSNI LVKRKKNGDG DAGSEGRSDE VDTILEKTYY DVDNHAPESL DWFNVLIAQT
190 200 210 220 230 240
ISSFRYEALQ SDNIYHSLKE FLSKSELPDY LGDIQLTEID IGDDFPIFSN CRIRPSKDSH
250 260 270 280 290 300
GRLEAKIDVD LSDTLTMGIQ TKLILNQPRP LTAVLPISLS VSIVRFSGCL TVSLINTNEE
310 320 330 340 350 360
EFSEPRVAMD SPQSTRDDNS EEPNGTALLF SFSPDYRLEF NVKSLIGSRA KLQDVPKISS
370 380 390 400
LIEHRLRSWF VERCIEPRFQ VVKLPSLWPR KKNTRQPVST TESDH