A5DF03

PR
Gene name
PRP28 (PGUG_01854)
Protein name
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Names
Species
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
KEGG Pathway
pgu:PGUG_01854
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5DF03

Entry ID Method Resolution Chain Position Source
AF-A5DF03-F1 Predicted AlphaFoldDB

No variants for A5DF03

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5DF03

No associated diseases with A5DF03

4 regional properties for A5DF03

Type Name Position InterPro Accession
domain Helicase, C-terminal 420 - 566 IPR001650
domain DEAD/DEAH box helicase domain 174 - 369 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 169 - 396 IPR014001
domain RNA helicase, DEAD-box type, Q motif 150 - 178 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
nucleic acid binding Binding to a nucleic acid.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRPLNAAELL KSRSQDHKLA KPQFLSKKKR LELQRAKEDE EREKTELKRK TNTLKRSSPS
70 80 90 100 110 120
EPETILDQKD TSTANKKRKK RFNFEWDDEE DTSSQLEPMM AYPTSNNDFL PAEEHWSDKK
130 140 150 160 170 180
LEDMTSRDWR IFKEDFSITC KGNNIPNPLR SWKESGIPTT LLNTIDQLGY KEPTPIQRAA
190 200 210 220 230 240
IPTALGHRDV VGIAETGSGK TLAFLIPLLS YLSAIDKDYM EVEHKQESNL NKVLGLVLAP
250 260 270 280 290 300
TRELALQISK EAKKFASVLG YNVVTIIGGH QYEETVKSVQ DGAHIVVATP GRLIDSAEKG
310 320 330 340 350 360
LIDLSQCYHL TMDEADRMID MGFEKALQSI LSFLPSTSSS GFGLDSTIFK VKSRITLMFT
370 380 390 400 410 420
ATISPPIEKI TKDYLQTPAY LYIGDAGEIV DNINQKFEYL GDNVDSQEEL NAPRTNKMIS
430 440 450 460 470 480
ALRQHIRETE QPLIIIFANF KRTCELLSVE LSNQNVGSNI VIHGSKSQEA RESAIASFRE
490 500 510 520 530 540
HKVNVLIATD VAARGIDIPN VSLVVNYHMP KRFDEYIHRI GRTGRAGKSG ASLSFVDDGD
550 560 570
SEILVNLKSF LSKGTKRLPD WLLRHPAVQS LTLKD