A5DAD0

PR
Gene name
PAN2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
KEGG Pathway
pgu:PGUG_00235
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-137 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5DAD0

Entry ID Method Resolution Chain Position Source
AF-A5DAD0-F1 Predicted AlphaFoldDB

No variants for A5DAD0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5DAD0

No associated diseases with A5DAD0

8 regional properties for A5DAD0

Type Name Position InterPro Accession
repeat WD40 repeat 10 - 49 IPR001680-1
repeat WD40 repeat 144 - 181 IPR001680-2
repeat WD40 repeat 184 - 220 IPR001680-3
repeat WD40 repeat 245 - 284 IPR001680-4
repeat WD40 repeat 287 - 329 IPR001680-5
domain Exonuclease, RNase T/DNA polymerase III 892 - 1076 IPR013520
domain PAN2, UCH domain 499 - 813 IPR028881
domain Ubiquitin specific protease domain 499 - 839 IPR028889

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGWEEVSIL AAILYSFPAS KDPVTSLLFD SVHNLLWCGD SSGSARSFTP NAGYPFQLYP
70 80 90 100 110 120
YTKFPATTSP LPVVQQRNHS RGILSLSQNC VNLNSRRGLS QATFTAASVT DSANVLRNLS
130 140 150 160 170 180
CMTTLGTGND IIVGGTHSLG SLDMQKCVAT GFDHSGNLSF VDSVAKTLVL GTTDGTVELF
190 200 210 220 230 240
DTASNSSVKS FPAHSGLLSD MAVQGNYIAT CGYSARRRYD HKNSSAAGGT SYITDPLVHL
250 260 270 280 290 300
IDTRMMKSLS PIPFPNGASF VRFHPKLPNI VIVASSTGVL EFVDIFDQSK LNVYQVNMSP
310 320 330 340 350 360
ASPGISRMEI SDNGEYICCS EGRSLHLWSF TSDTNFVNFP APLEEQDIPA PLPPPFEVDD
370 380 390 400 410 420
PVPLSSVGMP YYKDYLLSNY ATDMVFTKEL SKVPAEVDTS LGHGAFVPYD RTAHGPRNIS
430 440 450 460 470 480
QPYQSLREPP GSNSNAPRFI SERDGESNEN MIHAENSIFH LKSPTSVPHC YSRLQIQYSK
490 500 510 520 530 540
FGVDDFDFDY YNKSNGACSG LENHLDNSYT NALLQLYRAA PAFYNSVVES LLPEYLPNGP
550 560 570 580 590 600
EIISWNPQGS SLLIELGYLF DMMHKAEGRN VKIANFSQLL TQSASAASAG VINTDEEKSL
610 620 630 640 650 660
NADGLREIII RFNHYLLSEL TSNQRERRHT NSEKIEDIMG IKLEMQIKSQ CTETETHTGS
670 680 690 700 710 720
QLIFDLTSPP EQYLNKLAML RRAEKTEITI LSYMDYFMDQ YKSASCRECE ARGRPHAVNA
730 740 750 760 770 780
RQRVVRLPKV LSINLSMTNF ELQQIHNCRG WLVPEFHIGE DERFVDAGRG RKYELLGYVC
790 800 810 820 830 840
EISHGPGVKR GAHNLVSFVK IKGQWYLFND FLVMPIAQEE ALNLSYSWKK PVIIVYSEPG
850 860 870 880 890 900
QDFSYFETST FKKIQDLDTS IIYRDHFVRA AREGHRQEYK LLTKQEAPEI GTLIAIDAEF
910 920 930 940 950 960
VVSEPEQLEI RYTGTRKLIK PKKLTLARVS VLRGNGPNIG VPFIDDYIVW TGHIEDYLTS
970 980 990 1000 1010 1020
FSGIEPGDLD PEVSKKALVT LQTVYRKLWL LLNMGCVFVG HGLQNDFRCI NLVVPKTQVR
1030 1040 1050 1060 1070 1080
DTADLFYLPE FKRKLSLKFL AYVLLKEKVQ TGNHDSVEDA YTALMLFQKH EELTRTGDLE
1090
TVLYQVYMEG QQRRFRAP