A5D5I2

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
KEGG Pathway
pth:PTH_0312
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1144-1224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5D5I2

Entry ID Method Resolution Chain Position Source
AF-A5D5I2-F1 Predicted AlphaFoldDB

No variants for A5D5I2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5D5I2

No associated diseases with A5D5I2

7 regional properties for A5D5I2

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 576 - 976 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 814 - 826 IPR007121
domain RNA polymerase Rpb2, domain 7 978 - 1050 IPR007641
domain RNA polymerase Rpb2, domain 2 127 - 310 IPR007642
domain RNA polymerase, beta subunit, protrusion 18 - 354 IPR007644
domain RNA polymerase Rpb2, domain 3 369 - 437 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 449 - 514 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAYPEKVGAR VRYNFGRLRE VLDLPNLIEV QRNSYKWFLE EGLREVFQDI SPIQDFTGNL
70 80 90 100 110 120
VLEFLDYTLG EPKYTVEECK ERDVTYAAPL RVKVRLINKE TGEVKEQDVF MGDFPLMTEK
130 140 150 160 170 180
GTFIINGAER VIVSQLVRSP GVYFDETIDP SGKKLYTATI IPNRGAWLEF ETDVNDHIFV
190 200 210 220 230 240
RIDRTRKIPA TVLVRALGYG TKAQVAELFN EDKNILETLA RDNTDSEEEA LVEIYKRLRP
250 260 270 280 290 300
GEPPTVDSAR SLLTSLFFDP KRYDLANVGR YKIQKKLKHG VLYRYGPNPD GKTVFDPYLK
310 320 330 340 350 360
KEVPQKREFI RELTKEDIIE TIRYLLKLMN GEGQVDDIDH LGNRRLRSVG ELLQNQFRIG
370 380 390 400 410 420
LSRMERVVRE RMTIQDVDVI TPQVLINIRP VVAAIKEFFG SSQLSQFMDQ TNPLAELTHK
430 440 450 460 470 480
RRLSALGPGG LSRERAGFEV RDVHHSHYGR MCPIETPEGP NIGLIGSLST YARINEFGFI
490 500 510 520 530 540
ETPYRKVDKE NRRVTDEIVY LTADEEEGYV IAQANAPLDE EGRFIEPRVN ARSPEIVVVP
550 560 570 580 590 600
ADRVDYMDVS PKQVFSIATA LIPFLEHDDA NRALMGANMQ RQAVPLLKAQ APLVGTGIEY
610 620 630 640 650 660
KAARDSGVVV IAKESGTVEK VTSTHIEIRN DRGYLDRYKL LKFTRSNQGT CVNQKPIVKK
670 680 690 700 710 720
GERVEAGQVI ADGPSTDYGE LALGRNVLVA FMPWEGYNYE DAILVSEKTV KEDYFTSIHI
730 740 750 760 770 780
EEYECDARDT KLGPEEITRD IPNVGEEILK DLDDRGIIRV GAEVRPGDIL VGKVTPKGET
790 800 810 820 830 840
ELTAEERLLR AIFGEKAREV RDTSLRVPHG ESGKVVDVKV FSRDNGDELP PGVNQLVRVY
850 860 870 880 890 900
IAQKRKISEG DKMAGRHGNK GVIARILPEE DMPFLPDGTP IEIVLNPLGV PSRMNIGQVL
910 920 930 940 950 960
EAHLGWAAKV LGYYVSTPVF NGASEESIFE ALKEAAFKES GLRSFMEKAG LNEEELIGAV
970 980 990 1000 1010 1020
ETAEKRAGSR EALIKEVEGA ESSGETIMAA IERTGLTAGM VNRLEEAGMT KKEILGAMKK
1030 1040 1050 1060 1070 1080
LLFARSGKMT LYDGRTGEPF DSPITVGYVY MLKLAHLVDD KIHARSTGPY SLVTQQPLGG
1090 1100 1110 1120 1130 1140
KAQFGGQRFG EMEVWALEAY GAAYTLQEIL TVKSDDVVGR VKTYEAIVKG ENVPEPGVPE
1150 1160 1170 1180 1190 1200
SFKVLIKELQ SLGLDVKVLS EDDQEIEIRE VEEDIGETAK ELGIDLQEGE LPEVEEADYS
1210 1220
EDVEDEDMFN EEFFNEDFDL EDDE