A5D3F4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
KEGG Pathway
pth:PTH_1061
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

378-469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5D3F4

Entry ID Method Resolution Chain Position Source
AF-A5D3F4-F1 Predicted AlphaFoldDB

No variants for A5D3F4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5D3F4

No associated diseases with A5D3F4

4 regional properties for A5D3F4

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 868 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 555 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTGNEIRESY LKFFEKKGHK ILPSASLIPL NDPSILWTAA GMVPFKPFFT GAAKPEYTRV
70 80 90 100 110 120
TTCQKCIRTP DIESVGKTAR HHTFFEMLGN FSFGDYFKES AIPWAWEFVT EHLRLPADKL
130 140 150 160 170 180
WISIFLDDDE AFEIWNKTVG VPAGRIVRMG KDTNFWEIGV GPCGPCSEIY VDLGAERGCG
190 200 210 220 230 240
SPECKVGCDC DRFLEIWNLV FIQFFKDEEG NYTPLTSKGI DTGFGLERVA SVMQGVPTNF
250 260 270 280 290 300
DTDLFREIMD FTAGLFGLKY GVDGRVDVAL KVIADHCRAI TFAVADGALP SNEGRGYVIR
310 320 330 340 350 360
RLLRRAVRFG RLLGIEDPFL HEVSGAVVRQ MGRVYPELVT QREHVFRVIR REEERFGETL
370 380 390 400 410 420
AQGTEMLNRL IAEARQAGSA VVSGEDAFRL YDTYGFPLEL TQEMAGEQGL TVDTDGFGRA
430 440 450 460 470 480
MEEQRQRARS ARQETDYISG RDAMFKKMRE EVGETVFVGY DALEATGRVL RIVQGGKRLE
490 500 510 520 530 540
SAQAGEEVEF ILDVTPFYAE SGGQVSDRGK VTAADLEVEI HEVTKPVENL FVHRGKVVAG
550 560 570 580 590 600
ILKEHDTVTA RVDPARRAAT CRNHSATHLL HKALKEVLGG HVNQAGSLVE PERLRFDFTH
610 620 630 640 650 660
YAAATPEELQ KVEELVNRMV LSALPVEAFE TSLAEARKMG AAALFGEKYG ERVRVVKMGD
670 680 690 700 710 720
FSLELCGGTH LRNTAEVGLF KLLGESSVGA GLRRIEAVTG EGALSYVKAK EEQLAEIARL
730 740 750 760 770 780
VKAAPHEAVR RVEGLLQTVR DLEAENEALQ ARLARYQVQD LMDRLREVKG VKVLAGQAAA
790 800 810 820 830 840
PDMDSLRGMV DLLRDRVGSG VIVLGSAGEN RVNLVAAVTK DLVEKGLHAG KLVKELAPVV
850 860 870
GGGGGGRPEM AQAGGKDPSR LKEALEKTYK AVESQLK