A5D243

PR
Gene name
dinB
Protein name
DNA polymerase IV
Names
Pol IV
Species
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
KEGG Pathway
pth:PTH_1498
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

357-402 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5D243

Entry ID Method Resolution Chain Position Source
AF-A5D243-F1 Predicted AlphaFoldDB

No variants for A5D243

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5D243

No associated diseases with A5D243

3 regional properties for A5D243

Type Name Position InterPro Accession
domain UmuC domain 5 - 187 IPR001126
domain DNA polymerase, Y-family, little finger domain 245 - 354 IPR017961
conserved_site DNA polymerase type-Y, HhH motif 170 - 199 IPR024728

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
magnesium ion binding Binding to a magnesium (Mg) ion.

3 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRCPILLADM NSFYASVHQA MEPRLKGKPV IVGGDPARRH GIVLAASVEA KACGVKTGMT
70 80 90 100 110 120
VREAAALCPQ GIFLKPRHSH YINFSARIIR IMKDFSPLVE PFSIDEAFMD VSGCGLLFGS
130 140 150 160 170 180
SLEIAVKLKA RIKNEVGVLC SVGVGPNKLL AKMAAGMQKP DGLTLLDFPD VPVKIWPLPV
190 200 210 220 230 240
RELFGVGSRL EKRLRDLNIH TIGDLARYPL QVLKQKFGLV GHILHLSASG IDYSPVDPCS
250 260 270 280 290 300
LERVRSIGHQ ITLPRDYWGY NEIKVVILEL CEIVCRRVRL GGYAGRTVSL TLKDTDFLWL
310 320 330 340 350 360
SRARTMNYPT ASADEVYRVA VQLLHQHWPP WKPVRMVGVS LAGLVKNRAE QLDLFGEAER
370 380 390 400
ARRLHAACDR IKDRFGEHSI LRAVSLTPAG VLRERGGEAK HG