A5D0W6

PR
Gene name
mutS2
Protein name
Endonuclease MutS2
Names
Species
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
KEGG Pathway
pth:PTH_1939
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

482-561 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5D0W6

Entry ID Method Resolution Chain Position Source
AF-A5D0W6-F1 Predicted AlphaFoldDB

No variants for A5D0W6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5D0W6

No associated diseases with A5D0W6

4 regional properties for A5D0W6

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 324 - 509 IPR000432
domain Smr domain 707 - 785 IPR002625
domain DNA mismatch repair protein MutS, core 9 - 312 IPR007696
domain MutS2 and Smr-associated SH3 domain 639 - 680 IPR046893

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKKALKRLE YHKVLEQLAA CSGSSLGREK IMAMEPLDNL QAILRKQEET SEGRKLLRLE
70 80 90 100 110 120
PFAEAGGWKD IRAQLRKAGQ GAILDPEELL AVADTLTAGR TIRKFFQDRQ EQYPLLYEVS
130 140 150 160 170 180
SALVSLPELE RKIKNAILPG GEVADGASPE LAQIRRRLAA AQAQVKEHLE HIIRSPSYQK
190 200 210 220 230 240
YLQEPIVTIR EGRYVVPVKI EHRSQVPGIV HDQSASGATL FIEPMAVVEK NNELRRLMAA
250 260 270 280 290 300
EKREIQRILA ELSAGVAQHA GPIGASLEAL GELDFIMARA RYSQKLDAWA PLLEGEACMD
310 320 330 340 350 360
IRRGRHPLLQ GEVVPIDIRL GADFDTLVIT GPNTGGKTVA LKTAGLLVLM AQSGLHIPAG
370 380 390 400 410 420
EGSRLGIFRQ VFADIGDEQS IEQSLSTFSS HMNNIVEIIG KAGPDSLVLL DELGAGTDPA
430 440 450 460 470 480
EGAALAQSIL EKLHSAGAKT VATTHYGELK DFALTRERVE NASVEFDAIT LRPTYRLLIG
490 500 510 520 530 540
KPGRSNAFEI AARLGLPEEV VKRARSFLTA EHIQAEELMR SLEKTQQEAE AERRRAAELA
550 560 570 580 590 600
SEARALKERY EKIEADLASK RESILSKAAE EAQALVRAAR LEAEAAVREL REKMAEEAAR
610 620 630 640 650 660
ERENAIREAR EKLRKLQQRV GRAVPEKTVP GEAPAGLRPG EEVFLTRYNQ KGYVLEPPGA
670 680 690 700 710 720
GGEVLVQVGV IKMNVPLREL RRVKEARPAG GQSEVAGVLL NKAREISPEL DLRGLYADEA
730 740 750 760 770 780
LLEVEKYLDD AYLAGLSRVY LIHGKGTGSL RAAIHRQLSG HRRVKSFRLG EHGEGGLGVT
VVELA