A5CX61

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Vesicomyosocius okutanii subsp Calyptogena okutanii (strain HA)
KEGG Pathway
vok:COSY_0322
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5CX61

Entry ID Method Resolution Chain Position Source
AF-A5CX61-F1 Predicted AlphaFoldDB

No variants for A5CX61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5CX61

No associated diseases with A5CX61

4 regional properties for A5CX61

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 28 - 631 IPR002300
domain Zinc finger, FPG/IleRS-type 917 - 943 IPR010663
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 675 - 856 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 631 - 781 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKSSLNL PSTQFSMKAN LANREGKFLK KWQNDRLYDQ IRKQNQGKPK FVLHDGPIYA
70 80 90 100 110 120
NGDIHIGHAV NKVLKDIIVK SKSLSGFDAP YVPGWDCHGL PIELNVEKEY GKVGIKIDVN
130 140 150 160 170 180
TFRYKCREYA DHQVMRQSQD FQRLGILSDW DNPYLTKDFK YEADVVRALG QVVKNGHVYK
190 200 210 220 230 240
GHKPLHWCTE CGSALAEAEV EYKNKQSEAI DVKFRIIEDS VFNVKKPVSV VIWTTTPWTL
250 260 270 280 290 300
PANEAVALHS ELNYVLVDIG SEYLLLSQSL VVNSISRYDI KVTIGERMFS SSELEGLKVQ
310 320 330 340 350 360
HPFYDKQVPI ILGDHVTIDS GTGAVHIAPA HGQEDFIAGL KYNLPIDCPV DAKGVFFKEI
370 380 390 400 410 420
LLLGGQFIFK ANASVIRILK ETNTLVKHES LTHSYPHCWR HKTPIIFRIT SQWFISMQQN
430 440 450 460 470 480
GLRDIVNSEI QKVQWIPHWS KKRIELMVDN RPDWCISRQR FWGVPITLFV HKKTGELHPN
490 500 510 520 530 540
TQMLFVCIAN RIEQEGIEAW FKSDTKDFIG DDVNDYDKIT DILDVWFDSG MSHFVVLKVR
550 560 570 580 590 600
KELSNVADLY LEGSDQHRGW FQSSLISSVA INKKAPYKNV LTHGFVVDKD GKKMSKSLGN
610 620 630 640 650 660
IISPQKIVNN VGADILRLWI ASTDYTGEMT VSDEILKRSA DSYRRIRNTM RFMLANMNGF
670 680 690 700 710 720
TQKNLVDTKA MLDLDRWIVA KTQKIQEAII ENYDTYQFHY IVKSINNFCS NDLGGFYLDI
730 740 750 760 770 780
IKDRQYTTQK DSPARRSAQT ALYHITQMMV RWLSPILSFT SEEIWQELAP NKKSIFLQEW
790 800 810 820 830 840
YLQVDTIDNV VFDDGIIYGT MISSHISQEQ REGLEKSDDI FTSINIVRII SPTIRQAIEK
850 860 870 880 890 900
LRKDKVLGAS LEAEVDIYCN LKVKEKLSKF GEELRFMFIT SDVRLHSFEE KPNNAIEVDS
910 920 930 940 950
DVLQQVAIVV VKSEHSKCVR CWHHRKDVGS NNKYLELCCR CVENVDGDGE VRKFA