A5CD15

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
KEGG Pathway
ots:OTBS_0586
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

792-880 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5CD15

Entry ID Method Resolution Chain Position Source
AF-A5CD15-F1 Predicted AlphaFoldDB

No variants for A5CD15

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5CD15

No associated diseases with A5CD15

9 regional properties for A5CD15

Type Name Position InterPro Accession
domain Helicase, C-terminal 426 - 627 IPR001650
conserved_site SEC-C motif 860 - 877 IPR004027
domain SecA DEAD-like, N-terminal 6 - 391 IPR011115
domain SecA Wing/Scaffold 609 - 817 IPR011116
domain SecA, preprotein cross-linking domain 228 - 347 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 89 - 247 IPR014001
domain SecA motor DEAD 3 - 611 IPR014018
conserved_site SecA conserved site 489 - 504 IPR020937
domain SecA, C-terminal helicase domain 409 - 581 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMLKFIKSIF KTPSDRIIAN LKSKIQQVHS AESSLAKLSN IELRNKTSEF KARLANNEPI
70 80 90 100 110 120
DNIQYEAFAV VREAAKRTIG IQHYDEQLIG GILLHQGKVI EMSTGEGKTL VATLPSYLNA
130 140 150 160 170 180
LMGKGVHVVT VNDYLAQRDS DWMGTIHRFL DITVGCITSN TNEHARKIAY NSDITYITNN
190 200 210 220 230 240
ELGFDFLRDN MQFTNQSKVQ RGCNYAIIDE IDSILIDEAR TPLIISGPVS DNTSLYPIIN
250 260 270 280 290 300
KLITKLNKDD YEMDEKLRNV TLTDLGINKL ETMLAEINIL APNSNSLYDF ENMHLIHYIN
310 320 330 340 350 360
QSLKAHTLFR RNVDYLVKNG KVIIIDEFTG RTMDSRRYSE GLHQALEAKE KVEIQNENQT
370 380 390 400 410 420
LASITFQNYF RMYTKLSGMT GTAMTEATEL KEIYDLDVVT VPTHNPVQRI DYDDEIYSTK
430 440 450 460 470 480
KDKYSAIIQL IQECYSKGQP VLVGTVSIEK SEELSKLLHS KKIPHNVLNA KHHDKEASII
490 500 510 520 530 540
AQAGRIKAIT IATNMAGRGT DIMLGGNAEM LVDQSNLTEE EYQEKLKITK MQIEQEKEQV
550 560 570 580 590 600
INAGGLFVIG TERHESRRID NQLRGRCGRQ GDPGQTKFFL SLEDDLMRIF ASDRVTNILR
610 620 630 640 650 660
TIGLKDGEAI HHPLINRSLA TAQQKIEAQN YEIRKNLLKY DNVMNDQRKV IYEQRNEAIS
670 680 690 700 710 720
SDNVNEILHN LTEELIVETV HKFIPPKSYK EDWNIHGLVK EYHHIFNVKL QLDSIEATDS
730 740 750 760 770 780
SLKVIEYLTK TAFDIYKQQE QDYSAKSANE AIKHIFIKTL DQTWKEHLYT LDHLKQGISL
790 800 810 820 830 840
RAYGQKDPLN EYKREAFDLF KQMLLHLKYL FIQRVARLHI DLASSPKSTS SLLETSDNNL
850 860 870
KSKIITENSM AHKYFGKISR NQLCPCNSGK KFKHCHGALK