A5AAA4

PR
Gene name
int6 (An02g07120)
Protein name
Eukaryotic translation initiation factor 3 subunit E
Names
eIF3e
Species
Aspergillus niger (strain CBS 51388 / FGSC A1513)
KEGG Pathway
ang:ANI_1_982024
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5AAA4

Entry ID Method Resolution Chain Position Source
AF-A5AAA4-F1 Predicted AlphaFoldDB

No variants for A5AAA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5AAA4

No associated diseases with A5AAA4

2 regional properties for A5AAA4

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 257 - 436 IPR000717
domain Eukaryotic translation initiation factor 3 subunit E, N-terminal 32 - 163 IPR019010

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.

1 GO annotations of molecular function

Name Definition
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

3 GO annotations of biological process

Name Definition
eukaryotic translation initiation factor 3 complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex.
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAANVPPSAE TLLSGAAAHP PKTAEEIANQ YDLLPKLIPY LDRHLVFPLL EFSSGSQEDD
70 80 90 100 110 120
KEMIRAKYEL LKHTNMTDYV ANLWKEINDS DTIPDEFVKK REEVLAKLQH YQEQSAKITE
130 140 150 160 170 180
LLQDEDVVGN LRSDKVANLK FLEEEHGVTA DMVNSLFDYG RFQYSCGSYG NAAELLYQFR
190 200 210 220 230 240
VLSTDNDKVA SATWGKLASE ILTTSWDGAM EEVQKVKDSI ETRLFNNPLG QLQNRSWLIH
250 260 270 280 290 300
WSLFPFFNYD PARDVLTDLF FSPAYINTIQ TSCPWILRYL AAAVITNRNR AHKNSNVYQK
310 320 330 340 350 360
QLKDLIRVVR QEGYEYSDPI TDFVKALYVD FDFEEAQKKL GEAEDVLRSD FFLVSAADAF
370 380 390 400 410 420
VEAARHLISE SYCKIHQRID IKDLSTRLGL NQDEGEKWIV NLIRDTRVDA KIDYKEGTVI
430 440 450
MNHPPQSVYQ QVIEKTKGAF FRTQVLSAAV AK