A4YIL8

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
KEGG Pathway
mse:Msed_2131
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4YIL8

Entry ID Method Resolution Chain Position Source
AF-A4YIL8-F1 Predicted AlphaFoldDB

No variants for A4YIL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4YIL8

No associated diseases with A4YIL8

2 regional properties for A4YIL8

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 98 - 406 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 409 - 552 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTMELEEIVY KYALWNAVKH NGQAQVGPVV SKVFAERPEL KANAKEVVKL AEKMVAKVNA
70 80 90 100 110 120
MSLEQQTAEL QKYPELLEER KKEEKKTLSP LPNVKGTVVT RFAPNPDGPL HLGNARAAVL
130 140 150 160 170 180
SFEYAKMYKG KFILRFDDTD PKVKKPIKEA YDWIRDDLRW LNITWDLEFK ASERMSAYYN
190 200 210 220 230 240
VAKVMLEKGF AYVDTLSDAE FKAWRDSRNK TVYKPRTNPP EVNLELWEKM LNGDFDEGKA
250 260 270 280 290 300
VVRIKTNPED PDPSKIDWVM LRIIDTKRNP HPIAGDKFRV WPTYNFATAV DDHEFGITHI
310 320 330 340 350 360
LRAKEHTTNT EKQRWVYDYM GWEMPTVLEF GRLKLEGFMM SKSKIRGMLE TGSERDDPRL
370 380 390 400 410 420
PTLAGLRRRG IIPDTVREII IQVGLKVTDA TISFDNIASV NRKLLDPVAK RLMFVREGVL
430 440 450 460 470 480
FKLEIPQEMK AKVPLIPARQ EFREIFVKPG DEIYLDKGDV EEGKVVRLMD LCNVKIEGDR
490 500 510 520 530 540
LRFLSQDLES AKRMGANIIQ WVKKSESKSV NVIKADPNKD VEEIRGYGEG YFETLKPGDI
550 560
VQLVRYGFAR VDSISRGEIT MIFAHE