A4YI31

PR
Gene name
hisG
Protein name
ATP phosphoribosyltransferase
Names
ATP-PRT, ATP-PRTase
Species
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
KEGG Pathway
mse:Msed_1943
EC number
2.4.2.17: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-270 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4YI31

Entry ID Method Resolution Chain Position Source
AF-A4YI31-F1 Predicted AlphaFoldDB

No variants for A4YI31

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4YI31

No associated diseases with A4YI31

3 regional properties for A4YI31

Type Name Position InterPro Accession
domain Histidine biosynthesis HisG, C-terminal 186 - 284 IPR013115
domain ATP phosphoribosyltransferase, catalytic domain 1 - 205 IPR013820
conserved_site ATP phosphoribosyltransferase, conserved site 143 - 164 IPR018198

Functions

Description
EC Number 2.4.2.17 Pentosyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP phosphoribosyltransferase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIAIPNKGR LQGPALQFLN SVGIKPMAND DRALMVPTSW EGVQLVTIRT EDIPNIVETG
70 80 90 100 110 120
AVDLGITGLD YVMESGADVE ELVKLDFGKS RLVLAVPMSW NIEDPRDMPK NVRIATKYHN
130 140 150 160 170 180
IARAYLERKG IEARLVKISG AAEIMPSLGA ADAIIDVTST GTTLKLHGLK PIDVVSESYA
190 200 210 220 230 240
MVIGNKNWMK SEEADRINLV LTMMKGALSA RGKKMIFMNV DDVNLEAVVS SLPAMLAPAV
250 260 270 280
SKLSNSNAWE VVTVTDEEML PEVIAKAKTA GARDIVVVNI EKVIK