A4YH91

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)
KEGG Pathway
mse:Msed_1638
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

444-517 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4YH91

Entry ID Method Resolution Chain Position Source
AF-A4YH91-F1 Predicted AlphaFoldDB

No variants for A4YH91

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4YH91

No associated diseases with A4YH91

4 regional properties for A4YH91

Type Name Position InterPro Accession
domain DHHA1 domain 768 - 899 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 691 - 734 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 64 - 590 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 60 - 747 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKGNQEEYRL KFFLDHDYLR RECKVCKTPF WSKDKTREDC ADIPCSDYYF LDMKESNLNW
70 80 90 100 110 120
SVSEARRRFL DFFRRNGHEI IPPKPVLARW REDLYLTIAS IVDFQPYITS GISPPPANPL
130 140 150 160 170 180
VVSQPCIRMD DVDNVGITFG RHLTTFEMGG HHAFNYPDKF LYWKDETVAY AKEFFTKEMG
190 200 210 220 230 240
IPEELLNFKE SWWEGGGNAG PSFEVTVGGL ELATLVFMQY EIRDGEYVPL KLKIVDTGYG
250 260 270 280 290 300
IERLAWFTQK TPTAFHAIYG ELVDKFLEKL GLPSLNPDML KVASRFAGRI DPDVPSTIQG
310 320 330 340 350 360
HREQVAKAMG LPVKEVSEEL TRAARVFQVL DHTKTIALML GDGLVPSSGG EGYLGRLLIR
370 380 390 400 410 420
RALRTLKLLN VDVRLSELVD MQIGFWGKDF TQLVRNRDYI LDAVNLEQEK FNEILNRMSS
430 440 450 460 470 480
VVSSLTKKKE IGVEDLIQLY DSQGIPPDLM AEEMRSKGLK VEVPHNFYSI VAKRHQSAPV
490 500 510 520 530 540
KKEWDTTKLP PEVVKQVKDL PPTEKLYYKD QYARNFEGVI VKSLGKYLVL DRTVFYPEGG
550 560 570 580 590 600
GQLGDQGWLL LDGQRVKVVD TQKVGDVVVH VLEREISAKE GDKVKGEIDW VRRFRMMRHH
610 620 630 640 650 660
TGTHVVLAAA KKLLGDHVWQ AGAEKTPEKA RLDITHHRNL TREEVKRIEE MANLVVDDRR
670 680 690 700 710 720
PVTPFEINRT EAETKYGVSI YEGGVPNKAV IRLLEIKDWD VESCGGTHVA NTADIGGIKI
730 740 750 760 770 780
VNVEKIQDGI IRLEYVAGDV ISSYAGNLED KLEGLASKLE TSTSQIESRV EKLKEENERM
790 800 810 820 830 840
KELIAFYRRQ YLDDLEKHVE TRNVGKVKIV ILPSLKDEDL EREAMRRLTS TQGVVVIHVN
850 860 870 880 890 900
QVNGKLQIEI GTSKDLNVST VVTELVKAGG KGGGRGTFGS VMIEKGTKEE VIDIVERAIK
GGNS