A4YH38
Gene name |
thrS-cat |
Protein name |
Threonine--tRNA ligase catalytic subunit |
Names |
Threonyl-tRNA synthetase catalytic subunit, ThrRS-cat |
Species |
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) |
KEGG Pathway |
mse:Msed_1585 |
EC number |
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4YH38
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4YH38-F1 | Predicted | AlphaFoldDB |
No variants for A4YH38
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A4YH38 | |||||
No associated diseases with A4YH38
5 regional properties for A4YH38
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 214 - 423 | IPR002314 |
| domain | Anticodon-binding | 436 - 523 | IPR004154 |
| domain | Aminoacyl-tRNA synthetase, class II | 123 - 429 | IPR006195 |
| domain | Threonine-tRNA ligase catalytic core domain | 135 - 434 | IPR033728 |
| domain | Threonine-tRNA ligase, class IIa, anticodon-binding domain | 434 - 523 | IPR047246 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.3 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| threonyl-tRNA aminoacylation | The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESYRGLWLK | GAIVMALNMY | EAGLTPVEIG | LGERDFYIDV | QSDSALSLQE | SEKFAQWKDH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KYEIKDGKVT | YNGKQILLQG | DVTPSGEPRY | FKVLNISVHH | PSANVQLVRI | RGIAFETKEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MDDYLQWLEK | ASETDHRIIG | ERMDLFSFHE | ESGPGLVLFH | PKGQLIRNEM | INYMREINAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGYQEVYTSH | VFRTVLWKIS | GHYDTYRDKM | LIFQKDDDEL | GIKPMNCPAH | ILIYKSRVRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRDLPIRFSE | FGNVYRWEKK | GELYGLLRTR | GFTQDDGHIF | LREDQLKDEV | KNLVRKTLDV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGKFGFKGED | VRINLSTRPD | ESIGSDEQWE | KATKALLDVL | KELNVPYVVK | EKEGAFYGPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IDFDIRDSLN | RWWQLSTIQV | DFNLPERFKL | EYVDEDGSKK | RPVMVHRAIY | GSLDRMIAIL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEHFRGKLPT | WLSPVQVRVL | PISEDNLDYA | KRVMDVLVQR | GIRTEIDPSG | ETLSKRIKRG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YDDGVPYLVI | VGRKEASEEK | VTIRARGNVE | IKGVPLSRFV | DELSLEIGNR | DAENTLIKRI |
| G |