A4XSY1

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Pseudomonas mendocina (strain ymp)
KEGG Pathway
pmy:Pmen_1683
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

351-459 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4XSY1

Entry ID Method Resolution Chain Position Source
AF-A4XSY1-F1 Predicted AlphaFoldDB

No variants for A4XSY1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4XSY1

No associated diseases with A4XSY1

2 regional properties for A4XSY1

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 438 - 760 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 4 - 320 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALSHSLGFP RIGRDRELKK ALEAHWKGEL DEAGLRAVGQ RLRAEHWQLQ KDAGIDLLPV
70 80 90 100 110 120
GDFAWYDQVL AHSLAFDVIP ERFRPAAGKP TLDTLFAMAR GAVANKSGGS CCGGAHAQEM
130 140 150 160 170 180
TKWFDTNYHY LVPEFSADQQ FALSWEQLFE EVAEAHALGH SVKPVLIGPL TYLWLGKEKG
190 200 210 220 230 240
SDFDRLDLLE RLLPVYGEIF QRLAAQGVEW VQIDEPILVL DLPQAWKNAF ERAYNLIQRE
250 260 270 280 290 300
PCKKLIATYF GGLEDNLGLA ANLPVDGLHI DLVRAPEQYP TILDRLPAYK VLSLGMVNGR
310 320 330 340 350 360
NVWRCDLEKV LELLRHAHER LGERLWVAPS CSLLHSPVDL EREDQLDAEL KSWLAFAVQK
370 380 390 400 410 420
CQEVALLGRA LEAPDDASVQ AALEQSRVVR AARAASTRIH KPEVQARLAA IRPRHAQRQS
430 440 450 460 470 480
PFAERIAQQR ECLQLPLLPT TTIGSFPQTS AIRLARQSFK QGKLSAAEYT EAMHAEIRHA
490 500 510 520 530 540
VEVQENLGLD VLVHGEAERN DMVEYFAEQL DGYAFTRFGW VQSYGSRCVK PAVIVGDLGR
550 560 570 580 590 600
PQAMTVEWIK YAQGLTDKPM KGMLTGPVTM LMWSFPREDV SREVQARQLA LAIRDEVVDL
610 620 630 640 650 660
EAAGIRIIQI DEAAFREGLP LRQAAWQGYL DWATEAFRLA ASGVRDETQI HTHMCYSEFN
670 680 690 700 710 720
DVIESIAAMD ADVITIETSR SDMELLEAFE RFAYPNEIGP GVYDIHSPRV PDSAEMAGLL
730 740 750 760
RKAARRIPLE RLWVNPDCGL KTRAWPETEA ALVNMVAAAR QLRAELA