A4XL70

PR
Gene name
infB
Protein name
Translation initiation factor IF-2
Names
Species
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
KEGG Pathway
csc:Csac_2070
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-296 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4XL70

Entry ID Method Resolution Chain Position Source
AF-A4XL70-F1 Predicted AlphaFoldDB

No variants for A4XL70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4XL70

No associated diseases with A4XL70

6 regional properties for A4XL70

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 361 - 530 IPR000795
domain Small GTP-binding protein domain 364 - 520 IPR005225
domain Translation initiation factor IF-2, N-terminal 2 - 51 IPR006847-1
domain Translation initiation factor IF-2, N-terminal 284 - 335 IPR006847-2
domain Translation initiation factor IF- 2, domain 3 635 - 750 IPR023115
domain Translation initiation factor IF-2, domain II 536 - 631 IPR044145

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTNKLRIYEF AKLLEIQNKD LMDILNKLNI EHKNHMSALE ENDINLVLEY ILQEKEKEKE
70 80 90 100 110 120
HAEKRRERLP SHKEGRSGER QAKTFDEKKH TRHGEKASHP YDKRGEQKLQ QKSQQDVRQK
130 140 150 160 170 180
FDREKRERHQ EAIAKESGKK LEGQERKAVV HDQKVVELFP QQEPEKRQAA KPKYEVAKEQ
190 200 210 220 230 240
KIEKRYQDKV AAKQKTEKAT KHRKQLFNVD ELTQEEVTVD REELEKIDKE VEDTLLEEEY
250 260 270 280 290 300
LQEKHVRRGK KEKLKKRSKE QKEVLKLQTK TVQEEKKEEI VKIPEKITVG EFANLIGKPA
310 320 330 340 350 360
AEVIKKLIML GVMANINQEI DFDVASLIAE DYGFKVEKEI IKSEEEILLE DQEDPEETLQ
370 380 390 400 410 420
PRPPVVVVMG HVDHGKTSLL DAIRNTNVTE KEAGGITQHI GASVVEVNGR KITFLDTPGH
430 440 450 460 470 480
EAFTAMRARG AQVTDIAVLV VAADDGVMPQ TVEAINHAKA ANVTIIVAIN KIDKPEANPE
490 500 510 520 530 540
RVKQQLSEYG LIPEEWGGDT VFVNVSAKKK IGIDHLLEMI LLVADLLELK ANPNRPARGR
550 560 570 580 590 600
VIEAKLDKGR GPVATVLVQK GTLKVGDYVV VGSTWGRVRA MIDDKGQRIK EAGPSMPVEI
610 620 630 640 650 660
LGLEDVPTAG DELVCVKDEK TAKTIAQIRQ ERLKEEKMQQ SKISLDELFE RIQKGQLKEL
670 680 690 700 710 720
RVIIKADVQG SVEALKSAIE RLSNDKVTVK VIHAAVGAIT ESDVTLASAS DAIIIGFNVR
730 740 750 760 770 780
PEVGAMSLAE KEKVDIRMYR IIYDVINDIK AAMKGLLEPV YKEVIIGHAE VRQIFKSSSV
790 800 810 820 830 840
GTIAGCYVLD GKITRTSNAR IIRDGVVVYE GKLASLKRFK DDVREVAAGY ECGMTFEKFN
850
DIKEGDIVEA FEMQKVES