A4XKG3

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
KEGG Pathway
csc:Csac_1813
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

407-462 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4XKG3

Entry ID Method Resolution Chain Position Source
AF-A4XKG3-F1 Predicted AlphaFoldDB

No variants for A4XKG3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4XKG3

No associated diseases with A4XKG3

3 regional properties for A4XKG3

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 284 - 293 IPR020557
domain Fumarate lyase, N-terminal 15 - 309 IPR022761
domain Argininosuccinate lyase, C-terminal 372 - 439 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIQIKLWQGR FSKDTARIFD EFNASIMVDI NLFEYDVMGS VAHVKMLSKC DIIPEDEGKL
70 80 90 100 110 120
IVNTLYEILN DFKEGKIEFD MSDEDVHMLI EKELIKRIGQ VGKKVHTARS RNDQVVLDER
130 140 150 160 170 180
LFCREKNLYL QELIKNLIDT IIKLAEENID TIMPGFTHLQ KAQPVLFSHY ILAYAQMLKR
190 200 210 220 230 240
DLLRFRQNFI SINLNPLGSA ALAGTTFDID RFFVADQLEF DGVTENSIDT VSDRDFILEM
250 260 270 280 290 300
LFNIAMLQMH LSRLAEDFII FNTDEFRFIE LDDAFCSGSS IMPQKKNPDA LELIRGKTGR
310 320 330 340 350 360
TFGNLIGLLT VLKALPLSYN KDMQEDKEFL FDSIDTAEKS LIIVNEILKT LKVNKENMLL
370 380 390 400 410 420
ACKSGFINAT DLADYLVTKG VAFRDAHFVV GNIVKYCIEN NKSLEELSTE EFKRFCDKIE
430 440 450 460
EDVFKFISLE NCIKRRKSYG ATSPELVKKQ IENLKEFLRA YE