A4XJ42

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
KEGG Pathway
csc:Csac_1325
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

775-848 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4XJ42

Entry ID Method Resolution Chain Position Source
AF-A4XJ42-F1 Predicted AlphaFoldDB

No variants for A4XJ42

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4XJ42

No associated diseases with A4XJ42

9 regional properties for A4XJ42

Type Name Position InterPro Accession
domain Helicase, C-terminal 430 - 602 IPR001650
conserved_site SEC-C motif 829 - 846 IPR004027
domain SecA DEAD-like, N-terminal 5 - 398 IPR011115
domain SecA Wing/Scaffold 584 - 792 IPR011116
domain SecA, preprotein cross-linking domain 227 - 354 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 88 - 246 IPR014001
domain SecA motor DEAD 2 - 586 IPR014018
conserved_site SecA conserved site 496 - 511 IPR020937
domain SecA, C-terminal helicase domain 416 - 556 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKIIEKLIG SYSEREIKKI LPIVDKIESL APEYERLTDA ELRQKTDIFK ERLKNGETLD
70 80 90 100 110 120
DILPEAFAAV REAAWRTLKM RHFRVQLIGG IVLHQGRIAE MKTGEGKTLV ATLPAYLNAL
130 140 150 160 170 180
EGKGVHIVTV NDYLAKRDAE WMGPIYNFLG LSVGVIVHGL TSEERRKAYN CDVTYGTNNE
190 200 210 220 230 240
FGFDYLRDNM AIYKEELVQR ELNYAIIDEV DSILIDEART PLIISGPAEK STDLYKRADN
250 260 270 280 290 300
FVRRLKPLYY NSDDDKQMPD TTGYDYIVNE KRHTVALTEE GIKKAEKYFG VTNLADPENA
310 320 330 340 350 360
TLHHHIIQAL KAHALMKRDR DYVVKDGQVI IVDEFTGRLM YGRRFSEGLH QAIEAKEGVR
370 380 390 400 410 420
IERESRTLAT ITFQNYFRLY KKLAGMTGTA KTEEQEFREI YKLDVIEIPT HKPMIRIDHP
430 440 450 460 470 480
DKVYKTEKAK FEAIVEEIVE THKKGQPVLV GTVSIEKSEM LSEMLKKRGI KHEVLNAKHH
490 500 510 520 530 540
EKEAMIIAKA GQKGAVTIAT NMAGRGTDIV LGEGVAELGG LKVIGTERHE SRRIDNQLRG
550 560 570 580 590 600
RAGRQGDPGE SRFYVSLEDD LMRLFGSERI KRLVESLGLP DDQPIEHKLL SDAIEKAQKR
610 620 630 640 650 660
VEARNFEIRK HLLQFDDVLN KQREIIYSQR RKVLEGENLR DSILNMIDEL VDYKIKVYTG
670 680 690 700 710 720
ESPHPDDWDI KGLLQDLKFI FLDGELSEQD ARNMTKDELK EKLISIAKEK YLKKEQEVGE
730 740 750 760 770 780
LMRELERVVL LRVVDMHWMD HIDAVDQLRE GISLRAIGQK DPIVEFRFEA FEMFDQMIKR
790 800 810 820 830 840
IQEDTIKIIL HANVENMPKR ERVVKEMYEN SPSDAPVRKS VVKTQKVGRN DPCPCGSGKK
YKKCCGAV