A4XIX0

PR
Gene name
hslU
Protein name
ATP-dependent protease ATPase subunit HslU
Names
Unfoldase HslU
Species
Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331)
KEGG Pathway
csc:Csac_1252
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4XIX0

Entry ID Method Resolution Chain Position Source
AF-A4XIX0-F1 Predicted AlphaFoldDB

No variants for A4XIX0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4XIX0

No associated diseases with A4XIX0

4 regional properties for A4XIX0

Type Name Position InterPro Accession
domain AAA+ ATPase domain 49 - 357 IPR003593
domain ATPase, AAA-type, core 215 - 349 IPR003959
domain ATPase, dynein-related, AAA domain 52 - 126 IPR011704
domain Clp ATPase, C-terminal 356 - 453 IPR019489

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
HslUV protease complex A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

1 GO annotations of biological process

Name Definition
protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNELTPQEIV RELDKYIVGQ ERAKRCVAIA LRNRYRRAKL PKELQDEITP KNILMVGPTG
70 80 90 100 110 120
VGKTEIARRL AKLVNAPFVK VEATKFTEVG YVGRDVDSMV RDLVENAISL VKSEYMEKMK
130 140 150 160 170 180
ERAKALVEDR ILEILIPEPH ARKAGFKNPF EALFGAPSQE PEQTYQTTDD YIRTQREILR
190 200 210 220 230 240
EKLRSGELED KVIEVEVEDT VKPPFEMIMG TISDEMGISF QDVFGSLFPK KKKKKKMTIR
250 260 270 280 290 300
EAREVLEQEE YNKLIDMDEV IKEAIHRAEQ HGIIFIDEID KIAGRGSGVG PDVSREGVQR
310 320 330 340 350 360
DILPIVEGST VMTKYGPVKT DHILFIAAGA FHVAKVSDLI PELQGRFPVV VELHPLTEED
370 380 390 400 410 420
FKKILTQPKN AITKQYIELM KTEGVNITFT DDAIEAIAKV AVKINEQSEN IGARRLHTVV
430 440 450 460
EKIMEDISFE YANVEKPIDV VIDKDYVYSK VSDMIKDKDL NRFII