A4X5Z0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
KEGG Pathway
stp:Strop_1828
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

237-306 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4X5Z0

Entry ID Method Resolution Chain Position Source
AF-A4X5Z0-F1 Predicted AlphaFoldDB

No variants for A4X5Z0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4X5Z0

No associated diseases with A4X5Z0

4 regional properties for A4X5Z0

Type Name Position InterPro Accession
domain DHHA1 domain 749 - 889 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 669 - 712 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 572 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 725 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTAEIRRRY LAHFEANGHA VVPSAPLPAI SDPNLLFVAA GMMQFVPYFL GQQTAPYKRA
70 80 90 100 110 120
VSVQKCLRTP DIDEVGKTSR HGTFFQMNGN FSFGDYFKDE AIPLAWELST KPVDAGGLGL
130 140 150 160 170 180
DPDRIWPTVY LDDDEAFQIW RSVGVPADRI VRRGKADNFW SMGIPGPCGP CSELFYDRGP
190 200 210 220 230 240
EYGREGGPEV DEDRYLEFWN LVFMQFERGP GTGKEDYPIL GDLPAKNIDT GMGLERMASI
250 260 270 280 290 300
LQGVDNLYEI DEVRPILAKA AELTGKRYGA HSGQVASESH PDDVRLRVVA DHVRTALMLI
310 320 330 340 350 360
GDGVIPSNEG RGYVLRRIMR RAIRSIRLLG WQERAMPELL PVARDCMSAS YPELATDFGR
370 380 390 400 410 420
IADYAYAEED AFLSTLRAGT TILDTAIAET RTAGRRAISG AKAFQLHDTY GFPIDLTLEI
430 440 450 460 470 480
ASEQGLQVDA EGFRRLMADQ RARAKADAQA RKTGHVDLSA YRTVLDEGGP VTFTGYQEVS
490 500 510 520 530 540
RESTVRAVLG AASPHAAAVE GETVELVLDT TPFYAEGGGQ QPDLGVITVG GGQVEVLDVQ
550 560 570 580 590 600
QPVPGLIVHR ARVLRGEVRV GETGFAEIDT DRRRAISRSH TATHLVHQTM RNFLGESATQ
610 620 630 640 650 660
AGSLNAPGRL RFDFNTPTGV APSVLRDVEQ QVNEALLADL EVRAFVTSLA EARRIGAMAL
670 680 690 700 710 720
FGEKYGEQVR VVEVGDYARE LCGGTHVGRS GQLGLVKILS ESSIGSGVRR VEALVGIDAF
730 740 750 760 770 780
NFLAREHLLV ARLAELYRVP SDQVAERVEQ TVTQLRDAEK ELEKLRAQLV LGGAAALAAQ
790 800 810 820 830 840
ASEVRGVAYV GTEAPEGAAG NDVRTLAQEI RSRIDPARPA VVAVAARANG KASLVVAVNP
850 860 870 880 890
AARSQGLSAA DLVKVAFAGR GGGSPELAQG GGLPAAEAPG LLRTVENAIA GA