A4WMV7

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)
KEGG Pathway
pas:Pars_2178
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

175-248 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4WMV7

Entry ID Method Resolution Chain Position Source
AF-A4WMV7-F1 Predicted AlphaFoldDB

No variants for A4WMV7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4WMV7

No associated diseases with A4WMV7

5 regional properties for A4WMV7

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 186 - 336 IPR010918-1
domain PurM-like, C-terminal domain 548 - 654 IPR010918-2
domain PurM-like, N-terminal domain 73 - 174 IPR016188-1
domain PurM-like, N-terminal domain 416 - 534 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 1 - 38 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALSREELEV IERGLGRPPS EVELALFRSH WSEHCSYKST RMWLRRLPSR APWVVRGPGT
70 80 90 100 110 120
DAPLVEIAEG LFVTFKIESH NHPSAVDPYN GAATGVGGII RDILTVGARP VALLVNLHFG
130 140 150 160 170 180
PLDHPHARWI ASNVVRGISD YGNRVGVPVV GGETWFDEDF TYTPIVLATC VGVVEKGKVP
190 200 210 220 230 240
PGGVETGDLI VVAGLGADKS GLGGSAFASK TLREESEEDL GAVQVADPLM GKKLIDLVQE
250 260 270 280 290 300
AVGCVKFIKD LGGGGLATAL AELAEWFGLG VEAELDKIHM SDREMGPAEV LSSETQERLV
310 320 330 340 350 360
FVVSPQGLEC LKSLLEKYEV PYSVVGRFVK SGRVRLLWRG EVVGDVPVWL AAKAPEMVWP
370 380 390 400 410 420
RESYEPPPLP EIPEPPIDKA VELVLSSPNV AVKEAIYRRF DFDVGVRTAV KPGEGDAAVL
430 440 450 460 470 480
KLYERGNLGI VVKGDANPRY AYLDPRLGAA NAFVKAYRNV AVAGGVPKAA VDSINVGSPA
490 500 510 520 530 540
RPAVYWQFVE AVEGLKEAAE ALGVPIVGGK VSLYNEYGDR PIKPTVAVVV LGVIDDVSTA
550 560 570 580 590 600
LRALWRDGDG VYLWGFTRGE VGGSEYMYRV HRLVAGRPPS VDYAAEKRIV EEVQRWRGRL
610 620 630 640 650 660
TGAKDVGVGG LAAALAKMAV ASGVGADVDV CKAPTDMGRL DYLLFSESNG RFVAAGEEGP
670 680 690
GVKIGVAGGD RLVLRCGSTQ LFSRSVDGLK ELMSLGL